Roger has enormous growths on his nose that drip pus, attract flies, and are so large that he can barely breathe; Sandra and Jessie are sisters who bonded over their many undiagnosed face bumps.

Roger returns with his gigantic nose growths in the hopes that Dr. Lee and her colleagues can help before it's too late. Christine has lost her essence due to a large growth on her shoulder. Tiffany has a recurring cyst on her eyelid.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps. Leonardo has a fist-size growth on his head, but he is terrified of doctors. Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Monica returns for a second time in the hopes that Dr. Lee can remove some more of her face growths. Ken has several large cysts on his head that he has tried to remove on his own. Maranda has a mystery skin sore that causes her discomfort.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Keke is covered in bumps that make her embarrassed to be intimate with her husband. Jim is a widower with two lumps who wants them removed for himself and his late wife. Corey has been labelled a devil worshipper because of his forehead growth.

Stacey's shoulder growth prevents her from being the playful teacher she once was. Matthew worries that his mysterious shin rash may be dangerous. Both need Dr Pimple Popper's help to fix their skin.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches; Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort; Sharon has an embarrassing, stinky, squirting cyst under her breast.

Terry's nose growth has prevented him from meeting his grandkids; Remi has alligator-like skin and is not used to taking care of herself; Austin has an embarrassing birthmark right next to his eyelid; Mary Jo has a throbbing bump on her neck.

Jaclyn has a lump on the back of her head that causes her emotional distress. Shane has a growth between his eyes that could put him in danger at his electrician job. Brittany has seen multiple doctors about the sores on her body with no answers.