Yaellie, a sweet 9-year-old, has itchy psoriasis on over 90 percent of her body. Matt, a former Marine, has a large recurring lump in his armpit. Twins Tracie and Stacie have numerous matching bumps on their heads that sometimes leak.

James has a large, squishy lump on his forehead; Tanisha has a growth on her arm and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison; Justin has painful mystery bumps all over his head.

JD is a gentle giant with a pear-shaped mass hanging off of his ear; David has two bumps on his neck and one on his finger that give him pain; Julie hopes Dr. Lee can remove her large back growth so she can return to the sea.

Stephen's large, bulbous nose gets him unwanted attention, and he hopes Dr. Lee can help; Veronica wants to be free of secrets, including the bump on her butt; Marty has a large, 30-year-old growth on his shoulder that he is ready to remove himself.

John fears the large lump on his neck could become so big that it may eventually suffocate him. Shoshana is depressed because of the big growth on her forehead. Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

With pandemic safety protocols in place, Dr. Lee reopens her office. Monica has a large birthmark growing on the side of her face. Jackie has a melon-sized lump on the back of her shoulder. Reginald has large, rare growths on the back of his head.

Joanne has been held back from success because of her forehead growth; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

Dr. Lee tries to provide the help Reginald needs in order to remove two large rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; and Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head. Juan has a rare condition he hopes Dr. Lee will understand. Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

Audrey pops the painful bumps that cover her body so she can feel relief. Felicia has a peculiar looking dark growth on her forehead. Krista's excessive sweating is so severe that on any given day she could fill up an entire milk jug with her sweat.