Robert has a small keloid on his ear and a large, snakelike keloid on the back of his head that has been removed and returned three times. Angela has four growths on her head and hides away from those she loves out of embarrassment.

Gabriel has a huge growth on his clavicle but is terrified of surgery. Karen has dealt with painful, scaly feet for 22 years with no diagnosis. Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met "the one" yet.

Jeremy is a pastor with a hanging growth in an embarrassing location. Evelyn has recurring keloids that have been removed three times and come back bigger each time. Todd has a bump protruding from his forehead that is painful and humiliating.

Robert is back to see if Dr. Lee and Dr. Umar can remove his recurring head keloid for good. Justice has small lesions all over her body that get inflamed. Mike has hundreds of lipomas that bring him great discomfort.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jason has lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem. Jim has a growth protruding off of his nose, making it hard to breathe.

Roger has a considerable growth on his shoulder that he calls his "second head." Jenna is a bubbly teenager with an even bigger bubble behind her ear. Susan is covered head to toe in bumps that get in the way of her everyday life.

Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odor. Dusten is a cowboy looking to remove the painful lump on his knee. Ramiro has a bump on his jaw that has already been removed once.

Ruben is a personal trainer whose head growth has prevented him from seeing clients. Kaitlin has blue marks and scars up and down her arms due to long-term drug use. Adrian was left with a disfiguring bump on her behind after falling down stairs.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag. Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago. Amy has large growths all over her head that make her look like a hot mess.