April is covered in bumps that have disfigured her arms; Genner has flown all the way from the Philippines to have Dr. Lee help with his bumpy nose; Chris suffers from psoriasis that nearly covers his body and a bump on his head.

Matt has a skin condition that causes tumors to grow all over his body; Yamileth hasn't pursued her dreams because of the lump on her neck; Pat is covered with dark spots from her neck to her abdomen; Jennifer has a unicorn bump on her forehead

Louis is a veteran who is covered in scaly, dry skin that makes him feel like an alligator; Irais's kids are bullied because of the embarrassing growth on her head; Johnny has been living with a stubborn lump on his back for too long.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Patrick's nose is covered by huge bumps, and he can barely breathe; Aziza and Lauren are friends who bonded over their matching wrist lumps; Joe has a mound in the middle of his forehead that looks like a third eye.

Taylore is a beautiful young woman who has unsightly elf-like bumps on her ears; Jose never goes out because of the baseball-sized lump on his head; Ken is covered in painful bumps that make it difficult to do everyday things.

Barbara's back lump became more noticeable after she lost 131 pounds; Bob has two painful bumps on his back; Hilda's depression is a result of the multitude of bumps on her eyelids; Art has one big bump on his head that he covers up with hats.

Josh has a large knot on his head resulting from a car crash from 18 years ago; Brittney is covered in mysterious bumps; TJ has a hard, curious lump protruding from his side; Luis has a bump on his shoulder and his daughters fear it's dangerous.

Leonard has an alarming bump hanging off of his arm that looks like it's breaking through the skin; Brandon has several lumps on his head that make him fearful for his life; Jess gets a noticeable lump on her butt after falling down the stairs.

Eric hopes Dr. Lee is able to remove the giant growth from his behind. Breanna suffers from itchy dry skin she can't help but scratch. Michael makes jokes, but he knows the bump on his head is anything but funny.

Johnnie's crippling psoriasis keeps him from spending time with his daughter. Aimee has a Mohawk of cysts on her head. Edith's face markings and itchy skin condition turn out to be more than she expected.

Dr. Lee faces off with iguana-wrangler Madison's head growths. Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats. The dark purple birthmark on Eddie's nose has made him a recluse.

Robert has thousands of unique bumps on his arms that Dr. Lee has never seen. Alexis has a painful cheek cyst that oozes and has a pungent odour. Stuart's cluster of back bumps disgusts his wife, but thrills Dr. Lee.

Casey's birthmark covers most of her face, head and neck. James has mysterious massive growths on his inner thigh and lower abdomen that are completely puzzling. Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Elizabeth's head is covered with giant cauliflower-shaped bumps. Jamaal has been growing a strange knob on the left side of his butt since he was just a boy. Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Elaine calls the growth on her love handle her third breast. Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove. Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Bob suffers from mysterious open-wound sores all over his body. Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed. Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

John lost his sight at a young age and soon after began growing lumps on his body. Lynette has hundreds of pebble-sized bumps all over her arms, chest and belly. Gabe cannot imagine going off to college with the unsightly mole on the back of his head.

Steven's bump is so large, his daughter thinks he is growing a monster on his back. Catherine's arm lump has grown so big that it's nearly up to her armpit. Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag. Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago. Amy has large growths all over her head that make her look like a hot mess.

Ruben is a personal trainer whose head growth has prevented him from seeing clients. Kaitlin has blue marks and scars up and down her arms due to long-term drug use. Adrian was left with a disfiguring bump on her behind after falling down stairs.

Krystal, a witch, looks to clear a curse of a cyst from her face. Keven wants to get a butt lipoma removed to get his tush back into a regular shape. Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps. Leonardo has a fist-size growth on his head, but he is terrified of doctors. Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Monica returns for a second time in the hopes that Dr. Lee can remove some more of her face growths. Ken has several large cysts on his head that he has tried to remove on his own. Maranda has a mystery skin sore that causes her discomfort.