Casey's birthmark covers most of her face, head and neck. James has mysterious massive growths on his inner thigh and lower abdomen that are completely puzzling. Jerry had to hang up his rock star vocal cords when a lump grew out the side of his throat.

Tameru is a drag queen, but he has a myriad of cysts that are the real drag. Devon has uneven skin she thinks may be the result of a hysterectomy a decade ago. Amy has large growths all over her head that make her look like a hot mess.

Ruben is a personal trainer whose head growth has prevented him from seeing clients. Kaitlin has blue marks and scars up and down her arms due to long-term drug use. Adrian was left with a disfiguring bump on her behind after falling down stairs.

Elaine calls the growth on her love handle her third breast. Jessica's cyst is close to her eye and could be dangerous for Dr. Lee to remove. Dwayne wants his nose bumps removed, but he may not be able to make it through the pain of the procedure.

Bob suffers from mysterious open-wound sores all over his body. Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed. Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.

Steven's bump is so large, his daughter thinks he is growing a monster on his back. Catherine's arm lump has grown so big that it's nearly up to her armpit. Ethan suffers from an irritating rash in an uncomfortable and awkward place on his body.

Eric hopes Dr. Lee is able to remove the giant growth from his behind. Breanna suffers from itchy dry skin she can't help but scratch. Michael makes jokes, but he knows the bump on his head is anything but funny.

Krystal, a witch, looks to clear a curse of a cyst from her face. Keven wants to get a butt lipoma removed to get his tush back into a regular shape. Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.

Corey is a drag queen and has a bump dangling from his booty; Adam has a semi-circle of about a dozen cysts on his head that he covers with a hat; Virginia has large growths on both of her upper arms that make it difficult to travel in her RV.

Dr. Lee faces off with iguana-wrangler Madison's head growths. Chanel suffers from painful cyst tunnels beneath her armpit skin that leak and smell like the food she eats. The dark purple birthmark on Eddie's nose has made him a recluse.

Brittany has been called a monster due to her genetic condition that causes head-to-toe bumps. Leonardo has a fist-size growth on his head, but he is terrified of doctors. Tamyra has skin so thick that she shaves the bottom of her feet for relief.

Monica returns for a second time in the hopes that Dr. Lee can remove some more of her face growths. Ken has several large cysts on his head that he has tried to remove on his own. Maranda has a mystery skin sore that causes her discomfort.

Stacey's shoulder growth prevents her from being the playful teacher she once was. Matthew worries that his mysterious shin rash may be dangerous. Both need Dr Pimple Popper's help to fix their skin.

Lattyse was born with a mysterious growth above her eyebrow that gives her headaches; Robert has a tomato-sized growth on his butt cheek that causes him pain and discomfort; Sharon has an embarrassing, stinky, squirting cyst under her breast.

Margarita is a matriarch who has been hiding her armpit lump from her family; Kayla is an aspiring musician with a promising career that her painful eczema has brought to a halt; Bradley has a concerning growth that looks like raw meat on his leg.

Jason has lost confidence and motivation due to the large growth on his neck. Shawnell has multiple mystery bumps on her head that have destroyed her self-esteem. Jim has a growth protruding off of his nose, making it hard to breathe.

Roger has a considerable growth on his shoulder that he calls his "second head." Jenna is a bubbly teenager with an even bigger bubble behind her ear. Susan is covered head to toe in bumps that get in the way of her everyday life.

Debra has a large, brainlike growth on the side of her head that feels like a sponge, has crevices and emits an odor. Dusten is a cowboy looking to remove the painful lump on his knee. Ramiro has a bump on his jaw that has already been removed once.

Elizabeth's head is covered with giant cauliflower-shaped bumps. Jamaal has been growing a strange knob on the left side of his butt since he was just a boy. Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Belinda's lump on her neck causes her to basically be immobile; Nicole won't get married until she gets her arm pit lump removed; Adela's chest and back are covered in wisdom spots; Nick foolishly removed a lipoma at home and now needs Dr. Lee's help.

Lisa has a horn growing out of the back of her head and fears that it could be cancer; Victor has a bulbous lump on his chest; Chuck has a Popeye-shaped bump on his arm; Christian and Jonathan are teenage brothers with matching lumps.

David is back to see Dr. Lee after she spotted a suspicious growth under his eye. Nicole is depressed because of the bumps all over her neck. Steve has a noticeable lump on his forehead. Allen has a growth on his bicep but is terrified of doctors.

Keke is covered in bumps that make her embarrassed to be intimate with her husband. Jim is a widower with two lumps who wants them removed for himself and his late wife. Corey has been labelled a devil worshipper because of his forehead growth.

Gabriel has a huge growth on his clavicle but is terrified of surgery. Karen has dealt with painful, scaly feet for 22 years with no diagnosis. Lorne has embarrassing tumors on his face and body and believes this is why he hasn't met "the one" yet.