Lonely old women are being strangled, and Chief Ironside believes that there is more to it than just a serial killer at work. Setting Eve up as a potential victim requires a little ingenuity, but it might just prove to be worth the effort.

A notorious gangster is preparing to turn State's evidence when he is murdered, but Ironside pretends that the man is still alive, and ready to talk, in order to catch the killer and nail a major criminal.

When TV personality Francesca Kirby starts to receive death threats, her old friend Robert T. Ironside is soon on the case. When the threats become attempts on her life, he begins to delve deeper. Will he like what he finds?

A policeman known to Ironside for some years is shot dead whilst on an investigation. The evidence points to him being crooked, but the Chief is determined to prove otherwise.

Two killers break out of their cell in the precinct and hold Ironside and Eve Whitfield hostage, forcing the Chief to come up with a fool-proof plan for their escape. As always Ironside has a trick or two of his own up his sleeve.

Ironside is having problems keeping a group of local kids on the straight and narrow, and enlists the help of football star Bat Masterson, an old friend of Mark's. Bat's brother Joe, however, is a rather less savoury character, and Bat has to choose which side he is on.

A recently blinded woman is witness to a murder, and not knowing that she couldn't see him the murderer attempts to silence her. Ironside is on hand to protect her, and also to help her to come to terms with her new way of life.

An ingenious art theft takes place at Comus Towers Art Museum, and a guard is murdered in the process. Chief Ironside takes the case, but another death is to follow; this time the proprietor of the museum, who is an old friend of the Chief's.

A woman who wrote a cheering letter to Ironside when he was recovering from being shot, dies in an apparent suicide. Convinced that it was murder Ironside investigates, and uncovers the sad truth. (NB - As part of the incidental music, this episode heavily features the original song From The Day You're Born, which was reused later in the season, in episode Something For Nothing, where it was sung by guest star James Farentino).

Cars are being stolen in worryingly high numbers, and with the numbers recovered falling dramatically, the signs point to a crooked cop somewhere in the department. Mark is convinced that the cop in question is innocent, but nobody else seems very sure.

A friend of the Chief's turns out to have been living under an assumed identity for the last nineteen years, and is wanted in New York for murder. The mayor is determined to have him extradited back to NY for execution, but Ironside is equally determined to save him, especially when it becomes clear that he is innocent.

A local businessman sets up an organized vigilante force to try to clean up San Francisco. When a key member is murdered, it becomes clear that the "Second Force" has got severely out of hand.

An old friend of Mark's is a suspect in a murder investigation, but Mark refuses to accept that the man may be bad. Ironside tries to convince him otherwise, but in the process risks breaking his own friendship with Mark.

When Ed and two colleagues arrest a violent man they don't take his threats seriously, but when the other two officers are murdered, Ed is convinced that he knows who the killer is. Suspended from duty he sets himself up as the next victim, determined to prove that his suspicions are correct.

A cop goes bad and shoots a fellow officer, then offers to give himself up to Chief Ironside. Instead, he takes the Chief and Mark hostage, and plans to kill them as soon as his escape is certain. Ironside has to convince the man's wife that her husband is no longer the man she married.

During a night on the town, Eve Whitfield kills an armed robber who tries to shoot her. When he turns out to be a boy just turned seventeen, she doubts her abilities as a police officer, particularly when half of the town seems convinced that he was a model teenager. It soon turns out that this is far from the truth.

A friend of Ironside's turns out to be an amnesiac victim without a past. The need to discover who she really is comes to the forefront when somebody tries to kill her, and it becomes clear that the Chief's hopes for a long term relationship might not be possible with this particular girl.

Lecturing on a law course at a local college, the Chief finds that one of the students is planning to prove that the perfect crime can be committed. The person responsible appears to be particularly cold and calculating, and the Chief finds that he is facing true genius.

A baby is found abandoned in the Chief's van, following an explosion at an airport. The Chief suspects that the child's mother was the intended victim of the attack, and plans to make her come forward, using the baby as bait.

Ed is charged with police brutality following a raid on a hippie drug den. As always, of course, things are far from being as they seem, and the trail leads to a group of apparently model students at a local private school.

Mark's date is found murdered in Golden Gate Park, and he is determined to catch the man responsible, with or without Ironside's help. When he decides to take the law into his own hands, however, he finds himself under arrest for the murder of the chief suspect.

Mark's aunt Ruby is cheated out of her life savings by a pair of conmen, and the team set out to capture those responsible. Ed and Eve go under cover as a rich couple, but the investigation is threatened when Ed's cover is blown by a woman he once arrested.

Barbara Jones, the amnesiac victim with whom the Chief once fell in love (season one episode Barbara Who), calls Ironside in when her daughter is kidnapped. Not only is it a difficult case, but the Chief has an over eager Sheriff, a jealous husband and his own feelings to contend with, as he attempts to find the girl before it is too late.

As the team passes through a small town, Ed is kidnapped by an escaped convict. When it transpires that the real criminals are the local law officers, the pair go on the run together, and Ironside must get to Ed before he is killed by the Sheriff and his men.

Lured to a prison with a promise of information, the Chief and Mark are taken hostage by three convicts desperate to escape. Together they plot to undermine the escape attempt by turning the situation to their own advantage.