A rushed autopsy by Dr. Asten places Quincy in a difficult position as he tries to clear his bosses' name.

While working late at the lab Quincy and Sam are taken hostage by syndicate chief Vincent DiNardi. He has been poisoned and wants the two medical examiners to find out how the toxin was administered. Once he knows that he can make sure arrangements are completed for his revenge before he dies.

At 4 am one morning Quincy is awoken by the arrival of a man at his boat. He is in a very bad shape and he dies before Quincy can do anything to save him. He takes him to the morgue and does an autopsy on him. The next morning Quincy is surprised to find that his results and slides have not turned up. When he goes to find out why he finds out that they are not all that is missing, so is the body! Without any proof of a body everyone thinks that he must have been mistaken, especially when Monaghan visits the man's workplace and finds him there!

A young woman dies in a bar, apparently of a heart attack. After the autopsy Quincy is sure that something is not quite as it seems and soon discovers some unsettling facts about her husband.

When a kidnapper dies in a car crash after trying to pick up his ransom the only clue that will help the police find the missing boy is a half eaten apple. It is up to Quincy to use his medical expertise to uncover where the kidnapped boy has been hidden.

After dealing with what seems to be an open and shut murder case Quincy is ready to close his findings. Then he receives a request from a friend of his runs a program that helps old and young people work together. It seems that the suspect is one of the boys in his program and he doesn't believe that he could have killed someone. Not only that but the program could lose it's funding if it is true, and this would be detrimental to both the old and young it helps. Quincy promises to look into the matter and see if he can help.

Quincy is asked to cover for a GP working in a small community north of Los Angeles. There he becomes involved in a case of medical negligence after the death of a local man.

Quincy investigates the death of an eccentric millionaire, whose lavish penthouse was protected by a supposedly impenetrable security system.

After twelve people in a small town fall victim to a mysterious epidemic Quincy and Sam are sent on a mission to identify the disease, before the victims die.

Quincy stakes his reputation on his forensic findings, which suggest that an influential businessman is responsible for the death of his estranged wife.

A rookie cop and his partner are called to a break in at a shop, when they arrive they go into a dark shop and start to search it. The criminal is still inside and when they find him an altercation ensues and ends up with the rookie cop shooting the burglar. After an autopsy Quincy quickly discovers that the story the rookie is telling is not the truth. With a crusading TV reporter looking into police brutality Monahan wants Quincy to find out exactly what happened and why the rookie is lying before the reports condemn him and ruin his chance of a career in the police.

Quincy races against the clock to confirm that the skull of an apparent murder victim is that of a union leader who had disappeared two years earlier.

After a championship bout a young boxer collapses and dies. His wife thinks that it wasn't an accident and asks Quincy, a friend of her husband's trainer and the coroner on call, to see if he can find out how he really died. Once Quincy has completed the autopsy he begins to wonder if the woman is right, there is certainly something that does not seem to be quite right with the death, something that is made even more certain when Quincy is approached by 4 thugs who tell him in no uncertain terms that he better hurry up and make his report.

An alleged accidental drowning at a Health Spa pits Quincy against a slick attorney hired to prevent adverse publicity from affecting profits.

The sudden, unexplained death of a Japanese martial artist movie star leaves Quincy without an assistant. Sam quits after urging him not to perform an autopsy on the man, as it is against the religion of his parents. Quincy tries to balance his need for knowledge, to find out how the man died, and the feelings of his best friend.

When Will Preston, a western movie star and one of Quincy's idols, is found dead Quincy clashes with Lt. Monahan over what really happened to cause his death.

A man confesses to murder, thinking that he has killed his boss, but Quincy is not convinced that his blow was the one that killed the man and believes that he is not the guilty party.

Two labor leaders are fighting for votes from the farm workers in the Los Angeles area. When a young union worker dies, seemingly committing suicide by carbon monoxide poisoning, both leaders come under suspicion. Even more so when Quincy announces in a press conference that he is not convinced that it was suicide, and that it may have been murder.

Quincy has to persuade a group of hijackers that the plane they, and their hostages, are on has been exposed to a deadly virus.

An autopsy on a college football star reveals a congenital brain disease, and Quincy urges the victim's younger brother to stay out of the next high school game. But the boy's father and the school are determined to win the championship at any cost.