A doctor persuades a couple that their new baby, which was born with Down's syndrome, will not have any life outside of hospitals and institutions. The child is then allowed to starve to death, something that causes a second doctor to ask for the original one to be charged with murder. Quincy investigates and finds out more about how children with Down's syndrome are treated in the world. To do this he visits a family that look after six children on their own.

Quincy is going to be testifying in the appeal of a big mob boss, Victor Ramsay, and his evidence is vital to him staying in prison. Ramsay and his people have other ideas though and have a plan to guarantee his release. They kill the only witness and then set about making sure that Quincy is discredited. Once this is done Quincy and the D.A. have three weeks to come up with more evidence or Victor Ramsay will be released.

A man who was a prisoner in the Nazi concentration camps is run down and killed after he recognizes the man who was his tormentor in the camp. He manages to get a message sent to his friend, Heime, before his death and he tries to convince Quincy that it was murder, not an accident. At the same time Heime, who runs a Holocaust museum, has to deal with a rich, powerful man who spends his time proclaiming that the Holocaust never happened.

A German shepherd, bought as a family pet, savages and kills a young girl. Quincy investigates and finds out that there are absolutely no rules or regulations regarding dog trainers. He decides that he wants to do something about this but soon realizes that not only is this near impossible but that there is also more to this particular situation then it first seemed.

A nineteen-year old boy, with a malignant tumor, dies in a car accident. Quincy does the autopsy and meets the family. He goes to meet Dr. Pendleton, a doctor who deals with people who are close to death, and wants to learn how to deal with people who have just identified a loved one in a more dignified way. He spends some time with the doctor and even takes his place for a while.

Margo Bently is writing her first book, the contents of which could prove very damaging to a certain group of people. She is murdered and brought into the lab as a suspected alcoholic prostitute with cirrhosis but Quince thinks the body is telling him something different about her social standing. Quince is asked to present a seminar in Bufflo NY by Asten, while he's preparing his notes Asten takes over in the lab. In Quincys absence, Asten signs the body out to a phoney coroner and Quincy begins tracking her down. This leads him to a murdered literary agent in New York a race to autopsy him before he's cremated so he can prove a link.

A man is knocked down and killed by a drunk driver. Quincy is outraged to discover that the killer is likely to get away with a light sentence and tries to change things. His digging uncovers much more than he, and the prosecutor, could ever have expected.

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After running into an ex-girlfriend he had a fall-out with years ago, Quincey finds himself on the case when her husband dies and must unweave a diabolical plot to reveal the killer's identity.

A young woman is raped and strangled on a Los Angeles beach. Further down the coastline a young boy is shot and arrested for her murder. Quincy doesn't think that it would have been possible for the boy arrested to strangle the woman and decides that he is going to go out and begin a little investigation of his own. He visits City Hall where the woman worked to ask some questions and, after a little checking, finds out that there seem to have been a rash of unexplained deaths there.

Roberta Rhodes, a famous movie star, is found dead in her bedroom. The police think that it was probably suicide, but Quincy thinks not. A gossip newspaper editor approaches Quincy and tells him that on the night of her death his friend, and prospective senator, Congressman Charles Sinclair was with her. Quincy cannot believe that his friend could have killed Roberta but if he didn't then why does he keep lying to Quincy?

A truck driver dies just days after being splashed by a caustic chemical he was illegally dumping. Quincy uncovers the cause of his death and investigates further, trying to find where the chemicals were dumped before it rains and a dangerous chemical cloud is created.

An ex-nurse, who served in Vietnam and suffered nightmares because of it, is found dead in her apartment. Her best friend, who was also a nurse in Vietnam, tries to help find the killer but has problems of her own. She suffers her own nightmares from the war and begins to fall deeper into depression and alcohol. The same thing happens to many vets when they come back from the war and Quincy wants to help her, if he can.

Sam and Quincy are attending a job fair for students when a woman falls down an escalator, just after shouting at someone who has been following her. While she is in hospital it is discovered she has a severe case of posttraumatic amnesia. A high price assassin is caught in her hospital room not long afterwards and leads to even more interest in who she is and why someone would want her dead.

A big fire strikes at a hotel. The Coroner's Office is called in to deal with the fatalities. Most of the victims died from smoke inhalation rather than from the actual fire. Investigations prove it was arson and a suspect is quickly found. Quincy doesn't believe they have caught the right man though and helps out an insurance investigator, Jake Carter, look into it further.

Rear Admiral Mckenzie, an old colleague of Quincy's, dies while opening a naval museum named after him. A simple autopsy causes confusion for Quincy and Asten when they encounter a naval commander desperate for the body, 3 Mrs. Mckenzies and the presence of a microchip inside his stomach. Soon Quincy has his Naval reserve status reactivated and finds himself involved in the cat and mouse affairs of espionage and counter espionage.

A couple of cat burglars break into a Mexican museum and steal $4 million dollar's worth of jewels. Sealing them in the floor of their boat they sail to California with the intention of fencing them there. Once there one of their crew tries to steal the jewels but is caught. Alex, the main burglar, poisons him with the venom of a fish and dumps him into the harbor. Unfortunately for him Quincy and Lee are nearby and are called to help the dying man. Quincy not only gets there to help him but manages to save his life as well. He cannot at first work out what happened to the swimmer but is soon convinced that not all is what it seems.

Quincy and Janet finally get some time off and go on a weeks cruise. They are looking forward to some rest and relaxation together. Before long their holiday is interrupted. Quincy is visited, late one night, by the captain. One of his crew has been murdered and he would like Quincy's advice. The murderer is caught but he has died before the morning and an autopsy reveals that he could have died from an infectious disease. A disease that could already be spreading throughout the ship!

After a teenager dies from taking a seemingly harmless pill, Quincy sets out to shut down the highly dangerous, but legal, trade in ‘look-alike' drugs. He tries to find out why it is legal to make such pills and concentrates on closing down a small, local shop that sells the pills.

A family is violently murdered in their own home. The man arrested is the son and brother of the family members. He is a schizophrenic who blames everything on ‘The Beast', an alter ego inside his head who can take him over if he stops taking his medication. Quincy thinks, after talking with the DA, that he could be making it all up to get off on an insanity plea and tries to prove his theory.

A woman, Vicki Maguire, who has suffered from agoraphobia, manages to finally leave her house, for the first time in seven years. While walking her dog along the beach beside her house she looks in through the window of another house, and witnesses what she thinks is a woman being strangled. The police are called and when Monahan and Brill get to the house there is no body, no sign of a struggle and a completely different man in residence. No one believes her story, except for her psychologist Dr. Rainer, and she goes to see Quincy. She persuades him that the woman wasn't seeing things and that he should help her find out the truth, before she suffers a relapse and will never be able to leave her house again.

A fraternity ‘hazing' stunt goes badly wrong and a young man, Cary Stadler, dies. The other students panic and cover up how he died by placing his body in another place. Seeing as Quincy is the ME who deals with the case their attempt is very quickly uncovered. He proves that the story they are telling the police is complete fabrication. Proving they were involved and proving exactly what happened are two completely different things though, and there seems to be nothing that the police can arrest the boys for.

A young girl is injured in a car accident and rushed to a hospital by the paramedics. Her father who is severely injured is sent to a trauma center instead because he is a more serious case. The father survives and the daughter dies. The difference between a trauma center and an ER was what saved the man. City regulations make it hard for the center to get enough patients and it is about to get closed down unless Quincy can help.

With no doctor around and a shortage of staff, Lynn Buchanan, a nurse decides to ease a patients pain by giving him medication. The patient dies and nurse Buchanan is suspended, even though the doctor's chart didn't say she shouldn't have done it. The rest of the nursing staff go on strike, her suspension being the last straw. Asten gets Quincy to look a bit closer than normal (Quincy look closer than normal!) when he does the autopsy because his wife is in the same hospital and was looked after by Lynn Buchanan.

With the cruise ship being prevented from docking at any of the islands in the area it is down to Quincy and Janet to find out exactly what the disease on board is before everyone on the ship finds out and starts panicking.