A young woman is raped and strangled on a Los Angeles beach. Further down the coastline a young boy is shot and arrested for her murder. Quincy doesn't think that it would have been possible for the boy arrested to strangle the woman and decides that he is going to go out and begin a little investigation of his own. He visits City Hall where the woman worked to ask some questions and, after a little checking, finds out that there seem to have been a rash of unexplained deaths there.

Roberta Rhodes, a famous movie star, is found dead in her bedroom. The police think that it was probably suicide, but Quincy thinks not. A gossip newspaper editor approaches Quincy and tells him that on the night of her death his friend, and prospective senator, Congressman Charles Sinclair was with her. Quincy cannot believe that his friend could have killed Roberta but if he didn't then why does he keep lying to Quincy?

A couple of cat burglars break into a Mexican museum and steal $4 million dollar's worth of jewels. Sealing them in the floor of their boat they sail to California with the intention of fencing them there. Once there one of their crew tries to steal the jewels but is caught. Alex, the main burglar, poisons him with the venom of a fish and dumps him into the harbor. Unfortunately for him Quincy and Lee are nearby and are called to help the dying man. Quincy not only gets there to help him but manages to save his life as well. He cannot at first work out what happened to the swimmer but is soon convinced that not all is what it seems.

An old lady is attacked and killed in her own apartment. Quincy is horrified that someone could so callously attack an old woman and is determined to find evidence that will convict the killer. Later, after an evening visit to her apartment looking for more evidence Quincy himself is attacked and mugged, leaving him scared to go out in the dark and making him jump at every sound.

During an attempted armed robbery a hostage is shot by a police officer by accident. The police immediately suspend him and threaten to kick him off the force. He wants Quincy to use his forensic skills to defend him and prove that the shooting was righteous.

Quincy and Emily receive the use of a Judge friends' mountain cabin for their honeymoon. They picture a long romantic week alone, skiing and sitting in front of an open log fire. When they arrive they are disappointed to find that there are other guests as well. All the guests are involved in law enforcement of some form or other and all know each other. They soon realize that the last time they saw each other al together was on when they all worked on the same case, a year ago. The man they all helped convict escaped jail and has never been heard of or seen since. When the judge doesn't arrive they all decide to go out looking for him in case there has been an accident. When they find his car, caught up in a snowdrift blocking the only way down the mountain, and his body inside it they all begin to worry whether the missing criminal is planning his revenge.

The body of a young girl is found at the side of a highway. Quincy determines that the body was moved after she died. Monahan thinks that her boyfriend, Toby Kenyon, killed her but he tells the police that she killed herself. Quincy believes the boy and asks Emily to do a psychological autopsy on the dead girl. This involves talking to her friends, family and teachers about she acted and talked over the last few weeks of her life.

After a life saving heart bypass operation Ted Markham's brother dies from complications. He is incensed that his brother died from what should have been a simple operation. He wants, and pays for, an autopsy from the Coroner's office and Quincy is given the job. When he has completed the autopsy Quincy believes that the eminent surgeon, Dr. Royce, who was supposed to have done the operation didn't really do it. He thinks that a practice known as ‘ghosting' took place and that a young resident did the operation in his place.

At the end of a school day a young girl gets into a cab for her daily ride home. She doesn't arrive there and a search is soon started. The real cab driver is soon found and he gives a description of the man who attacked him and the cab is soon found abandoned and examined for forensic evidence. Then all of a sudden a man who fits the description walks into a police station. He is alone and refuses to confirm or deny anything. All he will let the authorities know is that Quincy and Professor Hillman (the kidnapped girl's grandfather) are covering up a murder.

Margo Bently is writing her first book, the contents of which could prove very damaging to a certain group of people. She is murdered and brought into the lab as a suspected alcoholic prostitute with cirrhosis but Quince thinks the body is telling him something different about her social standing. Quince is asked to present a seminar in Bufflo NY by Asten, while he's preparing his notes Asten takes over in the lab. In Quincys absence, Asten signs the body out to a phoney coroner and Quincy begins tracking her down. This leads him to a murdered literary agent in New York a race to autopsy him before he's cremated so he can prove a link.

When a young mother suffers from a nerve disease, Quincy fights the drug companies and the government to get her the medication she needs.

Michael Moroshima, a cop working undercover with the Asian task force and Sam's best friend, is killed while listening in on a deal between the Yakuza and the Mafia. Sam explains to Quincy all about the Yakuza and the Japanese code of honor that means his friend's father will try to find his son's killer and exact revenge. Sam tries to prevent this from happening but finds himself getting into deeper trouble himself.

A young boy, Tim, goes to do some welding at his workplace and ends up dying in an explosion. One of Asten's top field investigators, Arnold Chatham, thinks that it should not have happened. He discovers that Tim couldn't read and continues his investigation while Quincy tries to find out how someone who couldn't read managed to get through school.

An old lady is shot and killed by a burglar in her own home. When he arrives Quincy recognizes her as being one half of a couple of entertainers he saw in his youth. He remembers reading about their brilliance and wonders what happened to her old partner, Morris Perlmutter. He tries to find as much evidence as he can and then decides that he is going to find Morris. Meanwhile Morris is trying to get his big break in TV with the part of an old man in a play that is going to be broadcast live.

A medical examiner starts making basic mistakes, mistakes that are putting her job on the line and are caused by her alcohol binges. She is heading deeper and deeper into alcoholism and it may be that only Quincy can help her before she falls too far.

Quincy has to testify in the court of a small town. The witnesses in the case are pressurized into lying and Harry Muller, a bullying murderer, goes free. Within half an hour of the court case having been dismissed Harry Muller is found dead. The six men in the shop where he died all say they killed him, firing one shot each from his gun. The police chief is happy to call the death self defense but Quincy knows that it was murder and insists he will find out which one of them really killed him.

A sick woman with cancer leaves the hospital and dies. Those that have had physical contact with her die. Quincy soon discovers a new virus is the culprit of the deaths and hurries to find the cause.

Emily calls off the wedding when Quincy fails to make it to the rehearsal, the last straw as far as she is concerned. Quincy seems to be more interested in the tales Edna has to tell about her husbands' death. Was it murder as she claims or are her statements just the ravings of a mad woman?

When a young girl is killed in a drive by shooting a young 14 year-old boy is quickly arrested. The boy, Ethan, was part of a special program trying to get kids out of gangs and trouble. Ethan denies having had anything to do with the shooting, but if he doesn't tell who did do it or if Quincy and the probation people cannot find them then not only will he end up in prison but the special program will be closed down.

After his furniture warehouse is burnt down Ted Locke, a friend of Quincy's finds he is suspected of arson and murder. A lack of evidence makes the DA reluctant to press charges though. Enter Federal Prosecutor Philip St.John, he suggests avoiding a normal court trial and charges Locke with mail fraud, based on his claims for payment from his insurance company, which allows him to bring him before a Federal Grand Jury. When the ‘trial' starts Quincy discovers that there a literally no rules in a grand jury and the defendant can have no representation to help in defending himself. Quincy decides that he is not going to stand for this and tries to help his friend out.

Quincy and Emily's wedding is fast approaching and there are many things that still need arranging. Emily has brought in Winslow, a wedding arranger to help. While the wedding arrangements are proceeding a body comes into the coroner's office, an old man who died of natural causes in a rest home, just after his 65th wedding anniversary. After the autopsy the wife of the deceased man, Edna, comes in to see Quincy and tells him that she killed her husband.

A new pathologist (Walter Ross) is working in the lab who is disabled. When he looks into a case of electrocution of a handicapped baby (Sturge – weber disease) he is convinced that the baby was murdered by its father, Quincy's friend, Gerald Preston. Quincy is alarmed at Walter's blinkered view and decides to investigate Walters findings for himself.

A midwife, Olivia, is approached in the street and asked to help deliver a baby. She knows that she should not get involved but can see that the mother's friend is desperate for help. She goes to their aid but the baby dies in childbirth. The hospital they rushed the baby to when it became apparent that she couldn't help decides that her negligence caused the baby's death. The next thing Olivia knows she is being arrested for murder! Dr. Reed, a friend of Olivia's, visits Quincy and asks him to do his own autopsy on the baby. She hopes that he will find something that will help clear her friend.

An accident at a club leaves JJ Chandler, a top country singer, badly burned and in intensive care. Sgt, Wendell, a narcotics cop, believes Chandler freebasing cocaine caused the accident; the only problem is getting any proof, or a witness. While Wendell is trying to find someone who will testify Quincy begins to realize how many drug overdose victims he has dealt with during his time with the coroners office. He decides that there must be something he can do about it and means to do everything he can to stop the proliferation of drugs in Los Angeles.

A woman with psychic powers helps the police track down a serial killer.