Kenny Kelso, a young father, is seriously injured in a work accident and loses his arm. His arm is found and the paramedics take both him and his limb to a new place, Experiment Hope, where it may be possible to reattach them. The Doctor in charge, Gabriel McCracken, is the man behind the revolutionary new techniques and does everything he can to make sure that Kenny will be able to use his arm again.

Dr. Asten asks Quincy to stop of on his way to his fishing holiday to do an autopsy on a young boy. The coroner in the area wants back up evidence to help him close down the foster child home that was looking after the boy and other children. To help out one boy Emily and Quincy get the local authorities to try out a new scheme. The idea of this scheme is that a qualified therapist lives with the troubled family to try and stop any flashpoints from occurring, hoping that this will then enable the family to be able to live happily together.

Emily comes to see Quincy about a young 18 year-old boy he has just completed an autopsy on. He died while slamdancing at a punk rock club, killed while dancing to lyrics about death, lack of hope and violence. She had been counseling his girlfriend Abby and is worried about her. Quincy's report declares that the punk music Zack listened to was a part of the cause of his death but the main reason was an ice pick in his back. Punk music and its lyrics come under the spotlight as Quincy tries to find evidence to prove who killed Zack.

A woman with psychic powers helps the police track down a serial killer.

Monahan wants someone to examine a body that he thinks is involved in ‘smuggling' gems, a woman about to be autopsied is surprisingly found to be alive and Dr. Quincy is nowhere to be found. In his place is the brilliant, strict and feared Dr. Hiro.

When a potential Olympic champion is cut down in his prime his coach is accused of negligent homicide. A young lawyer, the only man who is willing to defend him, must rely on Quincy to find evidence to clear his clients' name.

Asten sends Quincy and Sam, at the request of Archbishop Vallejo, to San Remos, Mexico. They are sent to a small village where a young woman is seemingly curing people of their illnesses. She says that she gained her powers from some bones she found in a cave. Quincy and Sam have to join a group of eminent scientists trying to determine how old the bones are and whether they could possibly belong to a legendary missionary from the time of the Incas.

An accident at a club leaves JJ Chandler, a top country singer, badly burned and in intensive care. Sgt, Wendell, a narcotics cop, believes Chandler freebasing cocaine caused the accident; the only problem is getting any proof, or a witness. While Wendell is trying to find someone who will testify Quincy begins to realize how many drug overdose victims he has dealt with during his time with the coroners office. He decides that there must be something he can do about it and means to do everything he can to stop the proliferation of drugs in Los Angeles.

An autopsy on a college football star reveals a congenital brain disease, and Quincy urges the victim's younger brother to stay out of the next high school game. But the boy's father and the school are determined to win the championship at any cost.

A midwife, Olivia, is approached in the street and asked to help deliver a baby. She knows that she should not get involved but can see that the mother's friend is desperate for help. She goes to their aid but the baby dies in childbirth. The hospital they rushed the baby to when it became apparent that she couldn't help decides that her negligence caused the baby's death. The next thing Olivia knows she is being arrested for murder! Dr. Reed, a friend of Olivia's, visits Quincy and asks him to do his own autopsy on the baby. She hopes that he will find something that will help clear her friend.

Quincy has to persuade a group of hijackers that the plane they, and their hostages, are on has been exposed to a deadly virus.

Quincy continues in his quest to get close down Dr. Colella's surgery and stop him from continuing to issue prescriptions for drug addicts. This becomes less of a problem though after Marty Herrera, the young would be doctor, is arrested for killing Dr. Colella! Quincy doesn't believe the boy did it but finds that the evidence seems to be pointing straight at him.

A man is mugged and killed in a park, fortunately the killer is quickly found and arrested. Sometime later a gang member kills a young boy. The autopsy shows that the same gun killed the boy and the mugged man. Quincy takes it upon himself to track down the weapon and make sure that it cannot be used to kill anyone else.

When a young girl is killed in a drive by shooting a young 14 year-old boy is quickly arrested. The boy, Ethan, was part of a special program trying to get kids out of gangs and trouble. Ethan denies having had anything to do with the shooting, but if he doesn't tell who did do it or if Quincy and the probation people cannot find them then not only will he end up in prison but the special program will be closed down.

A new pathologist (Walter Ross) is working in the lab who is disabled. When he looks into a case of electrocution of a handicapped baby (Sturge – weber disease) he is convinced that the baby was murdered by its father, Quincy's friend, Gerald Preston. Quincy is alarmed at Walter's blinkered view and decides to investigate Walters findings for himself.

A well-known priest, who is running a crusade against pornography, is found dead in the room of a prostitute. She insists that he had a heart attack while she was ‘with' him. Monahan cannot believe that Father Terrell would have betrayed his principles and wants Quincy to look very closely when he autopsies the body. Quincy finds some discrepancies and wants to do a more detailed investigation, starting with Carlo Dicassa, noted pornographer and enemy of the father.

Two labor leaders are fighting for votes from the farm workers in the Los Angeles area. When a young union worker dies, seemingly committing suicide by carbon monoxide poisoning, both leaders come under suspicion. Even more so when Quincy announces in a press conference that he is not convinced that it was suicide, and that it may have been murder.

Quincy and Sam have to stay late, going over work that was completed by a Medical Examiner who, it turned out, wasn't qualified for the job. This makes Quincy miss yet another date with Lynne, his current girlfriend. When they do get together she proposes to him. He turns her down because he remembers how he treated Helen, his first wife. He was always working and never spending enough time with her. Later he feels guilty and decides to go and see Lynne and propose to her himself.

An old man at a hospital for respiratory disorders drops dead after going for a walk during a smog alert. Quincy's autopsy reveals lungs that had some kind of inflammation, caused by the pollutants being pumped into the air by the oil refineries near the sanatorium. Refineries that are meant to cut back their emissions during a smog alert!

A medical examiner starts making basic mistakes, mistakes that are putting her job on the line and are caused by her alcohol binges. She is heading deeper and deeper into alcoholism and it may be that only Quincy can help her before she falls too far.

Quincy has to testify in the court of a small town. The witnesses in the case are pressurized into lying and Harry Muller, a bullying murderer, goes free. Within half an hour of the court case having been dismissed Harry Muller is found dead. The six men in the shop where he died all say they killed him, firing one shot each from his gun. The police chief is happy to call the death self defense but Quincy knows that it was murder and insists he will find out which one of them really killed him.

After his furniture warehouse is burnt down Ted Locke, a friend of Quincy's finds he is suspected of arson and murder. A lack of evidence makes the DA reluctant to press charges though. Enter Federal Prosecutor Philip St.John, he suggests avoiding a normal court trial and charges Locke with mail fraud, based on his claims for payment from his insurance company, which allows him to bring him before a Federal Grand Jury. When the ‘trial' starts Quincy discovers that there a literally no rules in a grand jury and the defendant can have no representation to help in defending himself. Quincy decides that he is not going to stand for this and tries to help his friend out.

An old lady is shot and killed by a burglar in her own home. When he arrives Quincy recognizes her as being one half of a couple of entertainers he saw in his youth. He remembers reading about their brilliance and wonders what happened to her old partner, Morris Perlmutter. He tries to find as much evidence as he can and then decides that he is going to find Morris. Meanwhile Morris is trying to get his big break in TV with the part of an old man in a play that is going to be broadcast live.

A sick woman with cancer leaves the hospital and dies. Those that have had physical contact with her die. Quincy soon discovers a new virus is the culprit of the deaths and hurries to find the cause.

Quincy and Emily's wedding is fast approaching and there are many things that still need arranging. Emily has brought in Winslow, a wedding arranger to help. While the wedding arrangements are proceeding a body comes into the coroner's office, an old man who died of natural causes in a rest home, just after his 65th wedding anniversary. After the autopsy the wife of the deceased man, Edna, comes in to see Quincy and tells him that she killed her husband.