The Martini family moves to Poggio Fiorito, a residential area on the outskirts of Rome. Lele faces all the problems that the move entails. Luckily, his sister-in-law, Alice, is there to help him. The family's new housekeeper, Cetinka, causes chaos: as soon as she's hired, some money goes missing, and suspicion falls on her. But could this really be true? And are we sure she's from Poland?

Alberto, Lele's only grandchild, runs away from home and takes refuge at the Martini house because his parents are divorcing. Meanwhile, Grandpa Libero, to save money, starts selling musical pillows. Maria's birthday is coming up and she asks her father if she can celebrate alone with her friends. Lele agrees but is reluctant. Around the same time, Maria gets her period, and Rebby is the first to know.

Alice and Giulio, Lele's best friend, are worried because the doctor hasn't dated women in years, so they decide to set him up with a 35-year-old doctor named Irene. Lele's salary isn't enough to cover his family expenses. So his ex-father-in-law finds him a job at a private clinic that performs plastic surgery. Will this be the right fit for him?

Barbara, a young intern who courts Lele, arrives at the local health authority. Meanwhile, Giulio is admitted to the hospital after suffering a heart attack; will Lele's timely intervention save his life? Ciccio is struggling with his first love and would like to ask his father for advice, but Lele has other things on his mind at the moment. The trial regarding the accident that killed his wife Elena has begun.

Due to a sudden flood in his home, Giulio finds temporary shelter at the Martini house. Lele is obviously happy to lend a hand to his best friend... but only up to a point. Alice convinces Lele to sign up for a tango class with her. Sparks fly between them and they realize they're attracted to each other. But just then, Sergio, Alice's ex, arrives.

Grandpa Libero, attracted to piano teacher Maritè, takes some piano lessons from her, and Alberto and his friends start smoking against Lele's wishes. Laura, a colleague at the local health authority, is having problems with her ex-husband, and so Lele decides to help her, pretending to be her boyfriend. But it seems only Lele is pretending: Laura seems to have genuine feelings for the doctor.

Alice has an unusual mole appearing on her skin. She'll have to undergo surgery, and she wants only Lele by her side. This will trigger intense jealousy in her current boyfriend, Sergio. Sergio and Alice's relationship is becoming serious. Lele decides to openly confess his feelings to his sister-in-law, but the results aren't what he hoped for.

Sergio and Alice set a wedding date. At the Martini household, no one is happy about Alice getting married, and they're right: one evening, in fact, after returning home drunk, Sergio savagely beats Alice. Alice's wedding is annulled: fortunately, she has truly seen who she's dealing with. So, distraught, she moves into the Martini household. Meanwhile, an old flame of Lele's arrives at the clinic.

Grandpa Libero argues with his in-laws who want Maria to enroll in a very exclusive private school. Although things aren't going well, she's rather focused on her crush on a boy from her school. Irene's reappearance creates a lot of confusion in Lele's mind, so much so that he doesn't realize how unhappy Alice is. Meanwhile, Grandpa Libero's romantic relationship seems to be progressing.

Lele organizes a weekend reunion at the Martini house with all his childhood friends, offering them room and board, but over the years his friends seem to have changed significantly. Ciccio is sad because he didn't bring a good report card to his father, who scolded him. He meets Gus, a boy who lives and works at the circus, and decides to go with him and run away from home.

Great jealousy swirls in the air: Irene is angry with Lele because no doctor at the local health authority can resist his advances, while Maria is dealing with her first heartbreak. Not all the flirtations are welcome. Grandpa Libero tries to contain Marite's advances, while Alice must curb the editor-in-chief's "attentions." A surprise ending to Irene's birthday party.

Lele finally manages to spend a passionate night with Irene, but things get complicated when he decides to introduce her to his family. Meanwhile, Giulio is grappling with a serious problem. Lele's relationship with Irene has begun, but not everyone is happy about it. Especially Maria. Uncle Spartaco's arrival from America is welcomed as something to celebrate, but the visit hides a bitter surprise.

Maria continues to hate Irene, hoping that Aunt Alice will fall in love with her father, because to her they seem like a perfect match. Meanwhile, Cettina rejects her boyfriend's offer to live together. Lele discovers that Irene has hidden the news of her scholarship to Boston from him. She also doesn't intend to follow him to a friend's wedding in Milan. It's there that Alice and Lele meet again in Lele's room, alone.

Ciccio wears a hat lent to him by his girlfriend Susy, but it's full of lice, and the whole family becomes infected. Meanwhile, Alice and Giulio plan a night out, but it turns out to be a disaster. Lele and Irene argue after Irene discovers that Lele spent the night with Alice during the wedding in Milan; Irene is involved in a car accident, while Grandpa Libero's motorcycle is stolen.

A new doctor arrives at the local health authority: Dr. Oscar Nobili. One day, a gunshot is heard from the new arrival's room; it's a man attempting to commit suicide in front of Oscar. Lele will discover a secret. The Martinis go to Venice to visit Grandpa Libero's brother. After visiting the city, the Martinis separate. From this moment on, the trip turns out to be full of unexpected events, hidden just around the corner.

While Lele and Irene browse the stalls at the neighborhood festival, where Libero, Giulio, and Giacinto are also selling modern antiques, the Martinis' house catches fire. Lele is very worried: the insurance, having expired, doesn't cover the renovation costs of the burned house, and Ciccio confesses to having started the fire by playing with firecrackers.

Alberto hopes his mother has finally found the man of her life. Unfortunately, she has decided to resume her relationship with her ex-husband, which leads to a heated argument with her son. Alberto will remain at the Martini home. Irene, due to the expiration of her contract with the Rome Local Health Authority, must request a transfer. Lele tries to save their relationship and asks her if she wants to marry him.

Grandpa Nicola finally returns from Brazil, and Grandma Enrica decides to look in his suitcase and discovers a beautiful necklace. The unpleasant surprise, however, is that her husband returned three days early: he lied to her! Ciccio suspects an affair between his father Lele and his friend Susi's mother. Meanwhile, Alice is becoming famous, but her career seems to be jeopardizing her family's affections.

While Lele and Irene spend the weekend in Bologna, their new neighbors arrive, with whom Ciccio is having some problems. Meanwhile, Cettina argues with Alberto over his snobbish friends. At the Martini house, it seems like a maniac is stalking Cettina, but in reality it's just a misunderstanding. Meanwhile, Alessia Merz shows up at the local health authority, apparently interested in Lele.

A group of children from an orphanage arrive at the clinic for vaccinations. Among them is Robertino, a boy with Down's syndrome who mistakes Lele for Santa Claus and asks him for a new bus for the orphanage as a Christmas gift. Grandpa Libero has organized a show with Orietta Berti, but it looks like a scam. Alice and Irene will also have to work on Christmas Eve, and the magic of Christmas is struggling to arrive at the Martini house.

Ciccio searches for a girlfriend for Grandpa Libero in a lonely hearts magazine. Ricky, Jessica's boyfriend, ends up in a coma after a car accident. Maria, on the other hand, is invited by a boy she likes. At the radio station where Alice works, there's a health program. Lele and Alice are convinced the host is a charlatan, and even the local health authority is starting to worry about the show's success.

Alice gives Maria tickets to the Backstreet Boys concert, but Lele, worried, refuses to let her. Luckily, Grandpa Libero intervenes! Giacinto is fired, and it's up to Cettina to resolve the situation. Meanwhile, Jessica and Lele go to Ricky, who has woken up, but there's a nasty surprise lurking.

Ciccio steals from Grandpa Libero's wallet and, along with his friend Filiberto, skips school to go to the mall. But there, the two are threatened by other kids, who force them to give up the money. Lele finds a pregnancy test in Irene's locker and hopes for a child. But things aren't going to be like that, and in fact, Irene has been arrested at a doctor's office in Milan. This changes everything.

Maria hears the news of Leonardo DiCaprio's arrival in Rome to shoot a movie and goes to Cinecittà, where she meets Johnny, his bodyguard, and develops a crush on him. Meanwhile, Giulio decides to leave for Africa. Alice has been spotted with Tiberio Timperi, and Lele becomes jealous. Meanwhile, Giorgi discovers he's suffering from kidney failure, and everyone at the local health authority is worried, while Lele and Irene continue to argue.

The Martini family relaxes in the countryside, where Maria meets a boy who invites her to a party. But things go haywire: the boy becomes too insistent, to the point of becoming violent. But someone is ready to intervene. Grandma Enrica returns from Ponza with news: she's fallen in love with the owner of a fruit and vegetable supermarket, whom Alice doesn't like. Meanwhile, Lele decides to buy a ring.