Three years have passed since Guido's death, and the time has come for Maria to start over, even romantically. Meanwhile, Lele asks Bianca to take the plunge, but he discovers she's still married to her ex-husband. Bianca is determined to divorce him so she can marry Lele, who has since reunited with an old acquaintance, Virginia, while researching a rare disease. Furthermore, Annuccia faces trouble.

Bianca finds herself struggling on two fronts: seeking information about her ex-husband, and jealousy over Virginia, which grows despite Lele's reassurances. Maria receives a tempting job offer. Marco announces on the news that Nonna Enrica's D.O.P. mozzarella from Puglia is made with a different type of milk, not buffalo milk. The war begins!

Lele teaches a lesson on the environment at Annuccia's school and becomes a hit with his daughter's classmates. Meanwhile, Bianca's ex-husband, trying to put a spoke in her wheels, is determined to win over little Inge by any means necessary. A bolt from the blue strikes Bianca: the chocolate shop has been put up for sale. Furious and fearful for the future, she finds herself weighing her ex-husband Gus's offer. Meanwhile, Grandma Enrica plots to bring Maria and Marco closer together.

The Martini children are being bullied at school. When Lele and Bianca discover the situation, they convince the children to report the incident to their teacher. Bobò will be the one to demonstrate all the necessary courage. Lele's jealousy leads him to follow Bianca, who has left for the countryside with Gus and the children. Meanwhile, Maria helps Marco expose a clandestine gambling den.

Maria, with the help of her entire family, takes care of her little Palù and returns to work at the clinic. Grandpa Libero, who has left for America, entrusts Grandma Enrica with running the Apulian food products business. A hot air balloon ride offered by Gus turns into a cauldron of tension. Lele joins them as soon as he can, just in time to see the engagement ring he gave Bianca fall from the sky.

Grandma Enrica returns from the United States with a surprise that leaves everyone stunned: she's taken in a homeless man who leaves the whole family stunned. The Martinis' Christmas dinner is, as always, a seaport. And this year, on the day when everyone is at their best, Lele will give Gus a break.

Lele, due to the presentation of the research for the drug he's working on, is spending more and more time with his colleague Virginia. Virginia's ex-boyfriend, increasingly jealous, continues to harass the doctor. Maria feels guilty for not having devoted enough time to Marco lately. But when he shows up unexpectedly at her house, she'll be the one left speechless.

Ciccio is faced with a difficult realization: Tracy doesn't want to get pregnant because of the competitions she has to complete. Meanwhile, Maria doesn't believe Marco's explanations. Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's protests, she puts into action a foolproof plan that will cause a lot of problems, including for Lele.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he wants to propose a TV show. Both the clinic and the company that produced the drug are reported by the brother of the patient they were treating. Meanwhile, Marco and Maria discover that they truly like each other.

A ministry inspector comes to inspect the clinic after Virginia chooses to administer a drug not yet authorized. Marco receives an unexpected phone call and learns he must leave for Venice. Everything between Maria and Marco is going swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce from Gus at a crucial moment in their relationship.

Lele is determined to take control of his love life, telling Virginia there's nothing going on between them and declaring in front of his children that he'll do anything to win back Bianca, the only woman he loves. The discovery of Bianca's pregnancy deeply upsets her, and she decides to leave. Virginia will seek her out to explain the truth.

Like the baron in the trees, Inge decides to run away from home, just on the day Bianca is busy baking a birthday cake for Maria. The search begins. The search continues, and Gus finally finds his daughter at the farmhouse, suggesting she travel with him to Los Angeles. At the baby's first ultrasound, Lele and Bianca discover that Ciccio and Tracy are also pregnant.

At the Martini household, preparations are in full swing for Lele and Bianca's wedding. Little Palù is tasked with bringing photos of her parents to school, and Maria helps her daughter cope with the grief of Guido's passing. The big day has arrived, and everyone is ready to head to Ovindoli for Lele and Bianca's wedding. But as always in the Martini family, the unexpected is just around the corner. Will they make it?

Maria feels guilty for not having dedicated enough time to Marco lately. But when she shows up at her house by surprise, she'll be the one to be left speechless.

For Ciccio it's time for a hard discovery to accept: Tracy doesn't want to get pregnant because of the competitions to be achieved. Meanwhile, Maria does not believe Marco's explanations.

Inge is willing to do anything to spend her father's birthday at the farmhouse with him. Despite Bianca's remonstrances, she implements an infallible plan, which will cause many problems, even for Lele.

Ave receives an anonymous letter from a woman, in which she learns that Guido's heart has been transplanted into her son's body. Meanwhile, Giulio meets Magalli, to whom he would like to propose a TV format.

Both the clinic and the company that was involved in the production of the drug are denounced by the brother of the patient being treated. Meanwhile Marco and Maria discover that they really like each other.

An inspector from the ministry comes to check the clinic after Virginia chooses to administer an as-yet-unlicensed drug. Marco receives a sudden phone call and discovers that he will have to leave for Venice.

Between Maria and Marco everything goes swimmingly, and passion explodes. Meanwhile, Bianca discovers the truth about her divorce with Gus at a crucial moment in their relationship.

Lele is determined to take over the reins of his love life, making it clear to Virginia that there is nothing between them and declaring in front of his children that he will do anything to get back Bianca, the only woman he loves.

The discovery of a pregnancy deeply disturbs Bianca, who decides to leave. Virginia will look for her to explain the reality of the facts.

Like the rampant baron, Inge decides to run away from home, just on the day when Bianca is busy preparing a birthday cake for Maria. The searches begin.

The searches continue and finally Gus finds his daughter at the farmhouse, proposing to leave with him for Los Angeles. Lele and Bianca at the first ultrasound of the baby discover that Ciccio and Tracy are also pregnant.

At the Martini house, preparations are in full swing for the wedding of Lele and Bianca. Little Palù is given the task of bringing photos of her parents to school and Maria helps her daughter overcome the pain of Guido's disappearance.