While the entire Martini family is on vacation in Puglia, a mysterious man leaves an envelope addressed to Elena, Lele's late first wife, in the mailbox of the Poggio Fiorito villa. Valerio, Elena's former piano teacher, under the pretext of a rap concert, tries to get to know Anna and seems overly interested in the affairs of the Martini household. Meanwhile, Sara, without consulting Lorenzo, signs the preliminary agreement for the purchase of a villa.

Lorenzo learns that the tendon in his hand is damaged and blames Sara for the incident. Mortified, Sara decides to take a walk on the beach. There, by chance, she stumbles upon a party where, over beers, she meets Andrea. Completely drunk, the two end up in bed together. Sara and Enrica decide to track down Dr. Williams, who could operate on Lorenzo's hand, but the doctor is on vacation and refuses to work. The doctor's plans include to tour Rome in a carriage, but a strike prevents him. So Sara and Enrica decide to "steal" one and take him on a tour of Rome. To thank them, Dr. Williams agrees to operate on Lorenzo. Oscar's daughter Agnese returns to her father in the city, but he is busy and can't get to the station, so Tommy goes instead. Libero finds a letter in which Maddalena writes to a certain Francesco and, unaware that he is the Pope, believes that she is in love with the gardener of the parish she attends.

Maddalena is summoned to the Vatican for a private audience with Pope Francis, but Elena and Bobò are behind the summons letter. Anna, meanwhile, continues preparing for the medical school entrance exams, but her encounters with Valerio and Geko become increasingly frequent. Anna, accompanied by her grandparents and the Martini family's lucky teddy bear, takes the medical school entrance exam. Meanwhile, Lorenzo decides to admit Celeste, a young resident, to the operating room, but she panics and runs away.

Libero and Enrica invite Valerio to dinner to repay him. For this reason, Lele is forced to reveal the secret that binds him to the man. Meanwhile, Lorenzo hires Andrea to renovate his new house; when Sara meets him, she remembers the wild night she spent with him. Libero, still reeling from the revelation about Valerio, tries to attack the man, urging him to stay away from Anna. Meanwhile, Emiliano, at the suggestion of Ginevra, his new girlfriend, goes to Lele's clinic to hand over some money he owes to the young Martini, thus breaking all ties with the past.

It's Anna's birthday. To celebrate, young Martini gathers relatives and friends, including Valerio and Geko, at her house. At the end of the evening, Lele confesses the truth about Valerio and the paternity test to Libero, Enrica, Sara, Lorenzo, and Maddalena. Lele is determined to tell Anna the whole truth about Valerio, but he can't find the right moment to broach the subject. Meanwhile, Sara and Lorenzo are invited by Federica, Andrea's wife, to the same beach resort where Sara and Andrea spent their wild night.

Anna, having discovered the truth about her real father, is distraught and decides to lock herself in her room to be alone and reflect. Meanwhile, the Martinis finally decide to build a second bathroom in the house, despite Libero's resistance. Paolo, Bobò's best friend, reveals to Lele and Edoardo that he is gay and is at the mercy of school bullies. Meanwhile, Augusto, a plumber who immediately takes a liking to Maddalena, arrives at the Martinis' house.

Anna is increasingly struggling and has failed her entrance exam. Lele asks Carla to have Anna register for the Biology exam, which, once passed, will allow her to enter medical school. Anna, on the eve of her exam, is spending the night at a nightclub. Tommy and Agnese, who told their parents they were going to a film screening organized by the school, are at the abandoned factory.

To get revenge on Maddalena, Augusto brings his mischievous nephew to the house, who gets up to all sorts of mischief. After discovering Augusto's plot, Maddalena scolds him, but he tells her they're even. Upon learning the truth about Sara's betrayal, Lorenzo punches Andrea. Then he gives in to desperation and gets drunk. Meanwhile, the financiers for the new surgery department, which Lorenzo will direct, arrive at the clinic.

Ciccio returns to Rome to view a mare he wants to buy. He's warmly welcomed by the entire family and goes with Lele to Valerio's loft where Geko's album presentation is taking place. On the plane to Berlin, Sara meets Matteo, a concert promoter who gets her two tickets to a DJ's show. Lorenzo, annoyed by their friendship, tells his wife that something between them is broken forever.

Having learned of Lorenzo's crisis, Libero goes to the house to speak with Sara. She shows Libero a nearby grove, but just then, city gardeners arrive: the trees need to be cut down. Maddalena, deeply concerned about Rocco's situation, decides to go look for him. Libero accompanies her, but when they arrive at the address Maddalena indicated, they find a crowd of people at the door and an ambulance.

Rocco, who has settled into the Martini household, does nothing but eat and then lounge on the couch. When he says he's going to look for a job, Augusto and Libero follow him and catch him playing video poker. Lorenzo manages to operate on a little girl with a heart defect with his. Celeste and Lorenzo are overjoyed and congratulate each other. They leave the clinic together, hand in hand, but Sara catches them red-handed.

Lorenzo spent the night with Celeste. Sara decides to participate in the "Cuore a Cuore" association race, but Lorenzo refuses to sign the eligibility form because he deems Sara's competitive activity too risky. Jacinta goes to Poggiofiorito to meet Rocco and tell him she intends to get back together; Rocco is on the verge of giving in when he notices Libero and Enrica spying on them.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground after being hit. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of her identity. It's the day of the volleyball tournament final. The boys are excited and thrilled, but they realize their coach is distracted and has other things on her mind. Meanwhile, Lorenzo receives a bitter message from Sara.

Anna, on the eve of her exam, is spending the night at a disco. Tommy and Agnese who told their parents they were going to a school film screening, but they are at the abandoned factory.

In order to take revenge on Maddalena, Augusto brings a pestiferous nephew into the house who gets up to all kinds of things. After discovering Augusto's machination, Maddalena scolds him, but he tells her that they are now even and a draw.

Knowing the truth about Sara's betrayal, Lorenzo punches Andrea. Then he gives in to despair and gets drunk. Meanwhile, the financiers of the new surgery department arrive at the clinic, which will be directed by Lorenzo.

Ciccio returns to Rome to see a mare to buy. He is warmly welcomed by the whole family and goes with Lele to Valerio's loft where Geko's record is being presented.

On the plane to Berlin, Sara meets Matteo, a concert organizer who gets her two tickets for a deejay's show. Lorenzo, annoyed by that friendship, tells his wife that something between them is broken forever.

Made aware of the crisis with Lorenzo, Libero goes to the cottage to talk to Sara. The girl shows Libero a nearby grove but just then some gardeners from the Municipality arrive: the trees have to be cut down.

Maddalena, very worried about Rocco's situation, decides to go and look for him. Libero accompanies her, but when they arrive at the address indicated by Maddalena, they find a group of people in front of the door and an ambulance.

Rocco, who has installed himself bag and baggage in the Martini house, does nothing but eat and then lie down on the sofa. When he says he will look for a job, Augusto and Libero follow him and catch him while he is playing video poker.

Lorenzo manages to operate on a little girl with a heart malformation with his own. Celeste and Lorenzo are very happy and compliment each other. They leave the clinic together hand in hand, but Sara catches them in the act.

Lorenzo spent the night with Celeste. Sara decides to participate in the race run by the “Cuore a Cuore” association, but Lorenzo refuses to sign the eligibility form because he considers Sara's competitive activity too risky.

Jacinta goes to Poggiofiorito to meet Rocco and tell him that she intends to get back together with him; Rocco is about to give in when she notices the presence of Libero and Enrica who were spying on them.

Emiliano leaves the Raggio di Sole Center and finds Ginevra lifeless on the ground, after being run over. He calls an ambulance that takes the girl to Villa Aurora, where Lele is informed of the girl's identity.