Stan tries an experimental pill from the CIA and turns into a girl. Meanwhile, Klaus and Roger start a business selling Stan's suits as he no longer needs them as a female.

Hayley feels left behind after Jeff becomes a star dog racing coach; Steve takes advantage of an empty house.

Steve and Roger restart their career as a twin brother acting duo. The family becomes addicted to a novelty gift shop.

Stan discovers that the Langley Falls historical mural has been ruined by graffiti and neglect and convinces the town to allow him to restore the mural himself; Roger becomes Steve's instructor at a prestigious clowning university.

Jeff starts hanging out with Stan's favorite celebrity chef while in search of an identity. Klaus and Roger start their own valet operation.

Steve gets competitive during the father-son events at Possum Lake. Roger learns how to ride a bike.

Francine becomes obsessed with home security after a break-in rattles her. Steve tries on Hayley's laidback approach to school work.

When Hayley goes to a My Morning Jacket concert against Stan’s wishes, he crashes the show to bring her back home, but when he hears their music for the first time, it calls to him and he’s smitten. Stan becomes obsessed with the band and decides to follow them on the road as a groupie.

After her family accuses her of being a quitter, Francine becomes a bodybuilder. Klaus claims to have invented the high five.

Worried about their bickering, Stan and Francine go to extremes to save their marriage. Roger excels at jingle writing.

Stan and Hayley compete in collecting data for the US Census; Klaus has Steve and his friends model for his new camera.

Bullock asks Stan to fill in for him at his class at the CIA Academy and Stan finds that the cadets are the perfect captive audience for his boring stories; Klaus becomes the hype-man for a famous rapper

Steve tries to stop Roger after he joins a mysterious order of birds' egg thieves; Francine buys a new Italian sauce for the family.

American Dad becomes the 25th scripted primetime show in the History of Television to reach 300 episodes and Roger's past comes back to haunt him.

Francine becomes a conspiracy theorist when she finds out Stan has been shielding her from unhappy news; Klaus and Steve help Snot pimp out his basement.

Francine and Stan swap spouses with their gay neighbours Terry and Greg when Terry's dad, a former football player who doesn't know that his son is gay, arrives for a visit. Meanwhile, Steve goes on a drunken bender.

Upset that Hayley no longer wants his advice, Stan decides to prove that she is missing out on his sage counseling. After meeting a stripper on an important CIA mission, Stan takes it upon himself to improve her life and show Hayley that his advice works. But when he opens a new business, hoping to prove Hayley wrong, he finds himself dancing for cash to cover up his failures.

It’s Roger’s birthday, and he begs to be roasted, but when he ends up devastated by the jokes, he vows to pull his life together. Things take a turn for the worse when Roger takes it one step too far, causing the Smith family to go on the run

Steve goes to boarding school, only to discover it's an all-girls school. Stan is annoyed by a parade of characters that come to take Steve's place at home.

When Steve starts acting out his sexual energy, Francine asks Stan to give him the talk, but he makes Steve join a creepy father-daughter celibacy club with him instead. Also, the family builds a water slide in the backyard.

Hayley gets a job as a delivery driver and begins delivering lunch to Stan's office; when she sees the terrible work conditions, she organizes a strike; the family watches Breaking Bad in reverse and discovers the show is hiding a scavenger hunt.

Stan's co-workers at the CIA teach him about "rubbernecking," the art of checking out other women on the sly, away from the gaze of their wives. But when Stan causes a massive accident in an attempt to take a picture of an attractive jogger, he's interviewed by an intimidating insurance inspector who may rat out Stan to Francine. Meanwhile, Roger and Klaus spill wine on the Smiths' brand new couch, and vow never to tell the other family members by sitting on the stained spot for the rest of their lives.

Terry and Greg, the Smiths' gay neighbors, want to have a baby, and Francine offers to be their surrogate. Not surprisingly, Stan objects. Meanwhile, Steve and Roger play a practical joke on Klaus, who vows revenge.

Francine hosts a dinner party even though a serial killer who attacks dinner parties is terrorizing the town; when the lights go out and guests start to disappear, Roger takes charge of solving the mystery of who is stalking the party.

Stan is frustrated with traffic so he goes to the mayor and proposes that the town build a bullet train, but the mayor laughs off the idea; Roger pushes Stan into running for mayor; Stan wins the election but finds himself overwhelmed.