Any progress made during Revival Weekend in Savannah comes to a screeching halt after Mariah's meltdown on the bus. Dr. Jackie reaches her breaking point when she realizes that there are some problems she just can't fix. Contessa ponders Jackie's advice to pursue couples' counseling for herself and Scott. Mariah brings the receipts and the drug test results to prove Quad wrong, but do the rest of the ladies even want to know the truth?

Simone and Cecil ask for advice about their book from an old friend. Dr. Jackie gives a patient very important advice. Anila says her final goodbye to Ms. Gomez and wonders what is next for her. Contessa and Toya decide that enough is enough with Heavenly and stage an intervention on her shady ways. When things don’t go as planned, friendships are pushed to the limit.

The women continue their Vegas trip with a decadent dinner full of vintage wines, juicy conversation and some eye candy for dessert. Back in Atlanta, the men go boxing and old tensions between Kiran and Eugene resurface. A final brunch in Sin City turns into a second intervention attempt with Heavenly.

Quad's rumor-filled holiday party ends when instead of decking the halls, Audra tries to deck Toya in the face; Contessa meets with a new kind of coach to prepare for her fitness competition.

As the fun continues in Vegas, the ladies play a game where Toya reveals a secret she hopes doesn’t make it back to the ATL. Audra calls out Toya for questioning her skills as an attorney. The Vegas girls’ bonding trip is turned on its head yet again when the brewing dispute between Contessa and Heavenly rears its ugly head. Toya faces her greatest fears head on.

Heavenly admits to Damon that her mother's illness is affecting her, and offers a rare apology; Contessa feels for Heavenly, and agrees to put their differences aside.

Contessa reveals to Toya the reasons for her fractured friendship with Heavenly. Anila and Kiran receive some life-altering news. Heavenly opens a new business, partnering with the great beyond. Dr. Simone and Cecil start a new adventure together. Quad and Mason navigate their new life together. All the ladies come together for Heavenly’s grand opening for her new beauty supply store. Will everyone play nice or is someone’s weave about to be snatched?

As tensions in Toya and Eugene's marriage continue to grow, Heavenly confides to Jackie about the decline of her mother's health; Anila's parents arrive and immediately cause problems within the home.

In the aftermath of Heavenly’s intervention, she grapples with changing her ways. Contessa must decide whether to let go of one of her closest friendships. Anila tries to juggle work and her kids. A stunt by Anila and Kiran at the Halloween party goes awry, putting the husbands at odds with each other for the first time.

The Queen Bees of medicine are back with a vengeance. Friendships have been broken as Quad discovers long-time BFF Mariah has been talking behind her back. Meanwhile, Dr. Jackie shocks Dr. Simone with news that she wants a baby. Later, at Dr. Heavenly’s cocktail party, sparks fly as Toya accuses Dr. Simone of inappropriate behavior with Toya's husband.

Quad and Toya face off with Mariah in the courtroom, lending their support to Reco Chappelle, as he disputes Mariah's restraining order. Meanwhile, Jackie is visited by her stepdaughter Kursten, who reveals something surprising. Later, Mariah decides to extend a peace offering to all the ladies by inviting them to the launch of her new business venture. Then, after all her hard work, Lisa Nicole unveils her design collection to Atlanta and the world.

As the tension between former best friends Jackie and Simone reaches new heights, their husbands try and talk sense into them. Heavenly gets an unexpected call for a once-in-a-lifetime opportunity to help a young protester. Contessa enlists her niece Paris to throw a healing crystal event for the group. However, Toya brings along some blasts from the past to crash the party.

Everyone’s lives come to a halt when they have to isolate for 14 days. Toya discovers that Quad and Heavenly can't stop talking about her. Heavenly questions her son’s investment decisions. Simone thinks about adding to the family. Jackie surprises the ladies with a porn star, but Toya gets the real surprise when Anila confronts her about the rumors Toya's been spreading.

Toya finds calm at home even as her friendships remain rocky. Simone gives her son Miles an ultimatum. Anila finds a new job in an unlikely place. Contessa opens her new practice, but it’s the same old issues with Scott. Quad throws a game night party at her home, but the fun turns to drama, as Toya is forced own up to her past words about Quad’s house.

Anila and Quad bond over their shared issues with Toya. Simone and Contessa try to get to the bottom of Toya's problems with the group. Simone and Cecil host a couple's dinner, and are shocked to learn just how fragile Scott and Contessa's marriage is. Anila hosts a Holi event in hopes to heal some of the friendships within the group but things go Holi wrong when old feuds flare up.

Cecil and Eugene hang with Scott, who shares some interesting pics on his phone. Anila checks in on her house build and learns some upsetting news about her daughter. Heavenly and Zach put the final touches on their new rental property. Contessa uncovers some truths about herself. Simone plans a political town hall event, but things go off the rails when she discovers Lisa Nicole has been trying to push her aside.

The Town Hall Event is threatened when Simone learns some disturbing info about Lisa Nicole on the local news. Anila goes to Jackie for advice on her fractured friendship with Toya. Scott reveals a bombshell to Contessa that could undermine their entire marriage.

When Heavenly invites the ladies over for a dinner party, long-standing alliances are shattered as the ladies deal with the aftermath of Mariah and Quad's catwalk cat fight and are forced to choose sides.

Everyone gathers to relax by the pool prior to the March on Washington but can’t drown out the drama when Toya makes a splash and confronts Heavenly and Contessa. The doctors take a stand against the pandemic and systemic racism when they perform covid testing at the March on Washington. Later, after a day of unity, the ladies head to dinner but ditch two of their own.

In the season finale, the ladies enjoy a day of sightseeing that leads to some close encounters. Anila finds a creative way to get her money from Lisa. Later, the men join the ladies for the last night on the island. The truth about Scott and Contessa finally comes out, but will it create more questions than answers? [Part 2 of 2]

Jackie's date night with Curtis takes a surprising turn when she tells him about her plan to have a child. Meanwhile, Mariah talks her balding hubby into getting hair transplant surgery. After the showdown at Dr. Heavenly's, Toya and Dr. Simone meet to hash out their issues, but end up embroiled in even bigger conflict.

Host Andy Cohen reflects on some of the season's most talked about moments, as the MDs and Mrs. MDs come together in part one of the explosive Married to Medicine reunion. Mariah and Quad finally come face to face to reveal the truth about what really went down between them; Heavenly hears from the ladies on what they really think of her; Simone and Toya's disagreement on stage spills over to backstage, putting the rest of the Reunion in jeopardy. [Part 1 of 2]

The Married to Medicine Reunion continues as host Andy Cohen gets to the bottom of what happened backstage between Simone and Toya. The husbands join to shed their perspective on kids, sex and cheating. Later, Lisa Nicole dishes her grievances with Mariah. After hashing out new and old issues, can the ladies come together as a group again? [Part 2 of 2]

Simone prepares to send Michael off to college with one last Kids v. Adults basketball game. Anila wants to impress her parents with her new home, but momma isn’t impressed. Eugene calls Toya out for her recent cranky behavior. After an epic basketball showdown, Heavenly and Toya go into overtime, exchanging heated words.

The Doctors and Wives head to Washington DC for their most important medical mission yet as Ambassadors to the March on Washington. Reverend Al Sharpton and Ben Crump come by for dinner to discuss race relations in America. And tensions brew between the doctor's and the wives as Kari reveals to Toya and Anila that Heavenly and Contessa have been questioning their intelligence.