Any progress made during Revival Weekend in Savannah comes to a screeching halt after Mariah's meltdown on the bus. Dr. Jackie reaches her breaking point when she realizes that there are some problems she just can't fix. Contessa ponders Jackie's advice to pursue couples' counseling for herself and Scott. Mariah brings the receipts and the drug test results to prove Quad wrong, but do the rest of the ladies even want to know the truth?

Simone and Cecil ask for advice about their book from an old friend. Dr. Jackie gives a patient very important advice. Anila says her final goodbye to Ms. Gomez and wonders what is next for her. Contessa and Toya decide that enough is enough with Heavenly and stage an intervention on her shady ways. When things don’t go as planned, friendships are pushed to the limit.

The women continue their Vegas trip with a decadent dinner full of vintage wines, juicy conversation and some eye candy for dessert. Back in Atlanta, the men go boxing and old tensions between Kiran and Eugene resurface. A final brunch in Sin City turns into a second intervention attempt with Heavenly.

Quad's rumor-filled holiday party ends when instead of decking the halls, Audra tries to deck Toya in the face; Contessa meets with a new kind of coach to prepare for her fitness competition.

As the fun continues in Vegas, the ladies play a game where Toya reveals a secret she hopes doesn’t make it back to the ATL. Audra calls out Toya for questioning her skills as an attorney. The Vegas girls’ bonding trip is turned on its head yet again when the brewing dispute between Contessa and Heavenly rears its ugly head. Toya faces her greatest fears head on.

Heavenly admits to Damon that her mother's illness is affecting her, and offers a rare apology; Contessa feels for Heavenly, and agrees to put their differences aside.

Contessa reveals to Toya the reasons for her fractured friendship with Heavenly. Anila and Kiran receive some life-altering news. Heavenly opens a new business, partnering with the great beyond. Dr. Simone and Cecil start a new adventure together. Quad and Mason navigate their new life together. All the ladies come together for Heavenly’s grand opening for her new beauty supply store. Will everyone play nice or is someone’s weave about to be snatched?

As tensions in Toya and Eugene's marriage continue to grow, Heavenly confides to Jackie about the decline of her mother's health; Anila's parents arrive and immediately cause problems within the home.

The ladies of medicine return, but there has been drama in the ATL since the reunion in New York. Heavenly and Quad mend fences, but will it be as easy with Simone? Tea faces her swimming fears while Phaedra and Dr. G discuss the social media bombshell dropped by Heavenly. Simone and Cecil throw a Freaknik inspired party where an uninvited guest crashes and an old friend makes a surprise appearance.

In the aftermath of Heavenly’s intervention, she grapples with changing her ways. Contessa must decide whether to let go of one of her closest friendships. Anila tries to juggle work and her kids. A stunt by Anila and Kiran at the Halloween party goes awry, putting the husbands at odds with each other for the first time.

The ladies enjoy a day out on the ranch. Heavenly and Tea have a saloon showdown that threatens to derail the first night. Quad tries to get Contessa and Heavenly to reconnect. Jackie tries to get to the bottom of Heavenly and Contessa's failed friendship. Toya corrals the ladies for a "Cowboy Carter" photoshoot, but her diva behavior rubs the ladies the wrong way.

The "Cowboy Carter" photoshoot continues, but tyrant Toya threatens the fun. Back in Atlanta, Cecil teaches the boys the way around the kitchen. Eugene makes cologne with his kids. Damon's kids bring him to tears. Back on the ranch, things finally erupt between Heavenly and Contessa as old grudges resurface and new accusations are made. The ladies are left wondering how they can continue.

Toya reveals a secret from Mariah's past that infuriates her right in time for her husband's big birthday bash. Meanwhile tensions flair as Kari is setting up for the festivities and Mariah is nowhere to be found. When the queen bee herself show up two hours late the themed "Hollywood Glam" party turns into a "Hollywood Bash" that leaves guests in shock and a purse in the pool.

Quad throws herself a Paris-themed birthday party where she stuns the ladies by revealing a big secret. Simone continues to battle her issue with Quad, but a birthday invitation might be a step in the right direction. Dr. Jackie sees a celebrity patient. Dr.G and Sweet Tea wonder how Damon can take a back seat to Heavenly's bad behavior. Things get heated between the guys when Dr. G confronts Dr. Damon about Heavenly's behavior.

Heavenly throws Zachary a going-away party at their lake house. The ladies question Phadera's ability to raise money for the Med Gala. Phaedera gets defensive and has some choice words for the ladies. At the Med Gala, Dr.Damon tries to make peace with Dr.Greg. Dr. Contessa and Tea face Dr. Heavenly. Dr. Jackie is on pins and needles as she hopes the gala will meet the 100k.

The Queen Bees of medicine are back with a vengeance. Friendships have been broken as Quad discovers long-time BFF Mariah has been talking behind her back. Meanwhile, Dr. Jackie shocks Dr. Simone with news that she wants a baby. Later, at Dr. Heavenly’s cocktail party, sparks fly as Toya accuses Dr. Simone of inappropriate behavior with Toya's husband.

In the season finale, the ladies enjoy a day of sightseeing that leads to some close encounters. Anila finds a creative way to get her money from Lisa. Later, the men join the ladies for the last night on the island. The truth about Scott and Contessa finally comes out, but will it create more questions than answers? [Part 2 of 2]

Everyone gathers to relax by the pool prior to the March on Washington but can’t drown out the drama when Toya makes a splash and confronts Heavenly and Contessa. The doctors take a stand against the pandemic and systemic racism when they perform covid testing at the March on Washington. Later, after a day of unity, the ladies head to dinner but ditch two of their own.

Quad gets a very special, and expensive, gift from her boyfriend, King. Toya has advice for Eugene's new business, whether he wants to hear it or not. Simone and Cecil deal with their boys. Heavenly teaches her son the ropes in her dental office. Pheadra deals with Apollo and his marital affairs. Tea, Contessa and Phaedra come up with a plan to fix the group. The ladies all head down to Florida for a "Cowboy Carter"-inspired ladies trip, but will it be the medicine they need?

Toya shocks the ladies with her idea of an art class. Heavenly decides not to tell Damon about Toya’s explicit birthday party. While Simone and Cecil give the boys a safe sex talk, Jackie does some sexual research for an exciting new project. As Toya and Eugene move into their new house, Contessa surprises Scott with some big moves of her own.

The ladies finally arrive to Jekyll Island. Heavenly and Toya come together in hopes of starting anew, while Contessa confides to Jackie and Quad about her suspicions of Scott. The ladies relax at dinner, but their peaceful night is soon disturbed when Anila stirs the pot over a bad deal with Lisa Nicole. [Part 1 of 2]

Host Andy Cohen reflects on some of the season’s biggest moments as the ladies of medicine come together in part one of the explosive three-part Married to Medicine Reunion. After sharing how Covid flipped their world upside down, Quad graces the stage and shakes things up with Toya when she brings up the heated Instagram live debate. Anila and Toya’s friendship is tested, while Heavenly and Toya share a special kiss. Contessa reveals shocking information about her marriage to Scott. [Part 1 of 3]

Jackie's date night with Curtis takes a surprising turn when she tells him about her plan to have a child. Meanwhile, Mariah talks her balding hubby into getting hair transplant surgery. After the showdown at Dr. Heavenly's, Toya and Dr. Simone meet to hash out their issues, but end up embroiled in even bigger conflict.

After her disastrous birthday party, Mariah tries to make things right with the ladies. But sparks fly when Quad goes on the attack. When Kari fights back by disinviting Quad to an upcoming event her and Mariah are throwing, she not only ruffles Quad's feather she stings the queen bee herself. Meanwhile, Simone's patient deals with some potentially devastating news.

Tensions are high at a heated wine tasting when Mariah confronts Kari about Quad's disinvite to their joint party. Later when Kari and Quad agree to meet to sort out their problematic past, the road to resolution is anything but smooth. Meanwhile, Doctor Simone's sister brings out Simone's competitive nature during a visit and Doctor Jackie reveals a shocking secret that takes Quad by surprise.