Dr. Simone and Cecil head off to Hawaii to celebrate their 20th Anniversary with most of the couples in tow. However, Lisa is flying solo as Dr. Darren is missing in action. Dr. Jackie arrives with some baggage of her own, while Mariah starts the trip off on the wrong foot... can the ladies recover?

The Atlanta ladies are back! Quad has a new baby in her house, and Lisa Nicole’s got a baby on her brain. Dr. Jackie is moving on up while Dr. Simone and Cecil are adjusting to life apart. Toya is in big trouble with the IRS while Heavenly just stirs it up. Lisa Nicole throws a bash to bring the group together, but are the ladies ready to move past it all and have a new beginning?

Everyone processes the aftermath from Lisa Nicole’s party. Dr. Simone reaches out to Quad to make sure she understands why she came down on her so hard about having a baby. Genise reveals to Toya that she doesn’t find Heavenly so heavenly. Lisa Nicole takes her complaints about Toya’s behavior to her new best friend, Mariah who has decided to throw a new beginnings party and invite all the ladies. Is this really a new beginning or a to be continued?

Mariah’s new beginnings party ends in a new beef between Genise and Heavenly, and the beginning of the end for Toya and Lisa Nicole’s friendship. Simone reaches out to family to find her missing father, while Jackie tries to convince Curtis to give up the suburbs for the city. Meanwhile, Heavenly gets advice from Alaura about being a grownup, and later, three years of bad blood meet face to face as Toya and Mariah see if they can bury the hatchet.

Simone, Quad, and Jackie head to Nashville to search for Simone’s missing father. Heavenly does some soul-searching with her spiritual guide, Jewel Tankard; while Lisa Nicole and Darren also seek help from a professional, about their relationship. Meanwhile, Toya and Eugene have to deal with Avery’s discipline problems at school after a ‘peeing’ incident.

Heavenly and Lisa Nicole embark on a new business venture, but their collaboration quickly turns ugly, when Heavenly shares her true feelings about Lisa Nicole’s marriage. Simone is back at work after her emotional trip to Nashville with a transgender patient who wants gender reassignment surgery. Meanwhile, Jackie's topless charity photo shoot gets out of control causing her to expose a very different side of her personality. 

Hot off the heels of the look book photo shoot, the girls still can’t believe Jackie actually kicked them to the curb. Things heat up for Darren when he has to face the music after flaking on Lisa’s baby making plans. As the girls prepare to celebrate Toya’s 40th birthday, Simone finds out long awaited news about her father. Later, things hit a fever pitch with Mariah and Quad when they finally go head to head at Toya's birthday party.

After their huge argument at Toya's Prom Party, Mariah and Quad's friendship is on shaky ground. Quad is planning a birthday bash for Dr. G and doesn't want Mariah to bring her drama to the party, so she takes “extra” precautions. Toya faces the hard truth she can no longer afford the lifestyle she wants but when it's time to make changes she gets cold feet. Lisa's antics put Heavenly's patience to the test as they plan for their upcoming conference.

Toya and Eugene struggle with the big issue of moving into a smaller house. Jackie and Curtis near a code red as their marriage continues to take a backseat to Jackie's career. Mariah and Simone meet to get their friendship back on track, but a surprise revelation gives Mariah pause. Later, Toya treats the ladies to a spa day to get ready for Hawaii, but tempers erupt when Lisa decides she isn't laying down for Toya anymore.

It’s day two of their Hawaiian adventure! Jackie is still reeling from her solo trip to the Big Island and Dr. Darren is still nowhere to be found leaving Lisa Nicole all alone. The group bares it all, in couples therapy, but the exchange between Lisa and Heavenly is anything but therapeutic! A traditional Hawaiian luau may be what the group needs to dance away their troubles, when Toya tries to rally around Lisa and her marital woes.

On their last day in Hawaii, Simone has one more surprise for the ladies, but will the men be on board once they find out what's in store? Quad organizes a make-up photo shoot for Jackie and her Look Book, but a new fight over old wounds with Mariah threatens to ruin everything. Back in Atlanta, Mariah spills the tea on what she really thinks of Quad and her past. Later, Jackie tries to cure what's ailing in her marriage, but Curtis refuses to just roll over.

With only a week until their relationship conference, Heavenly and Lisa Nicole must work together to get everything in place. But once Heavenly hears that Lisa hasn't been entirely honest about their collaboration, the whole group finds itself having to pick sides once again. After spending months taking care of her family, Quad needs to celebrate herself, and she bares it all at her 35th birthday party! Toya and Eugene make the final leap in their financial journey as they move into a more affordable house.

Toya and Eugene may have downsized their home, but their new CPA now wants them to downsize their budget. Jackie springs a romantic surprise on Curtis, but is it enough to mend their fractured relationship? The fallout continues between Lisa Nicole and Heavenly as the two women put on dueling conferences... whose conference will the other ladies support? Later, tempers flare at Toya's housewarming party as Lisa and Heavenly finally come face to face for the ultimate showdown.

In the season finale, at Toya's housewarming barbecue the ladies continue to fight and when Mariah tries to intervene things turn ugly fast. Heavenly looks to her spiritual advisor when she faces a crisis of conscience while Lisa Nicole and Darren try to pick up the pieces. Dr. Jackie's look book is almost ready and she's hoping the upcoming sneak peek will provide a backdrop for friendships to heal and mend.

Host Andy Cohen reflects on some of the seasons biggest moments as the ladies of medicine come together in part one of the explosive Married to Medicine Reunion. Toya comes face to face with her tax problems; Lisa Nicole standing up against the blitz of confrontations from the other ladies about her marriage and underhanded business decisions; Mariah dishes her grievances with Heavenly, telling her what she really thinks of her, leading to a dramatic confrontation. [Part 1 of 2]

The reunion continues as Andy welcomes the husbands to tell their side of the story. Jackie shocks everyone, dropping a bomb about her relationship with Curtis; Darren confronts the women on the vicious rumors he can't escape, but Lisa ends up being his sharpest critic; Simone relives her darkest moments from the heart wrenching search for her father. After hashing out old and new issues, will the ladies be able to come together as a group again? [Part 2 of 2]