The first ladies of medicine are back and busier than ever. Simone and Toya’s friendship is on the fence, but when Toya decides to throw a Halloween party to show off her new house, her husband Eugene insists she invites Simone to bury the hatchet. Quad is full speed ahead with her puppy couture line but when Quad learns Lisa Nicole ran a background check on her for “business” reasons, the two have a fall out. Meanwhile, Dr. Jackie’s latest endeavor is to test out a lifestyle fitness program on the girls and hopefully everyone is willing to jump on board.

Dr. Simone and Toya are at odds but unlike their wives, husbands Cecil and Eugene are determined to save their friendship by forcing an olive branch into Simone and Toya’s strained relationship. Still reeling over Lisa’s surprise background check, Quad flips the script and hires a private investigator to dig up dirt on Lisa Nicole and her husband Darren. Later, Jackie and her trainer Al ambush the girls with a surprise invite to join her latest fitness venture.

Trying to find the root of her anger, Jackie helps Simone understand how her dad’s past transgressions are still affecting her life. As the ladies gather to celebrate Lisa Nicole and Heavenly's magazine cover, Simone comes face to face with Toya for the first time since their disagreement. Meanwhile, following a successful meeting with the private investigator, Quad receives all the information she needs to finally give Lisa Nicole a taste of her own medicine.

Hoping to move past the background check, Quad calls Lisa Nicole for an in-person meeting in hopes of teaching her a lesson in the art of friendship. Things take an unexpected turn when Quad makes a startling accusation which leaves Lisa Nicole reeling. Meanwhile, Heavenly prepares for a date with her hubby and enlists her daughter, Alaura’s help for some serious fashion guidance. Jackie hits the ground running and kicks off her new fitness program, “Fit Is the New It.” However, it is hard to concentrate on getting fit as word reaches the circle of friends about Quad and Lisa’s unexpected encounter.  

In order to regroup, Quad decides that taking some time away from the ladies is her best option. With fitness her top priority, Jackie goes into drill sergeant mode to snap Simone out of her bad junk food habits. Meanwhile, some of the ladies decide to spend some quality time at a strip club but it’s not all fun and games when Lisa Nicole learns that the establishment is one of her husband’s habitual stomping grounds.   

Still reeling from her visit to the strip club, Lisa confronts her husband in order to discover the truth. In hopes of being a supportive wife, Toya tries to get involved with her husband’s new business venture. Always the ones to inform and enlighten, Simone and Jackie demonstrate safe-sex techniques that embarrass some of the ladies and perks the interest of others. Meanwhile, through laughter and tears, Mariah and Quad try their best to mend their relationship but aren’t sure if they can dive back into their friendship.

Jackie comes up with a creative strategy to whip the girls into shape in the second phase of Fit Is The New It. Meanwhile, an anxious Simone is happy when her sister comes to town to hold her hand through her son’s first date. Wanting to settle the score once and for all, Lisa Nicole meets with her attorney to discuss legal options against Quad, while Quad brings in high-powered attorney Phaedra Parks to weigh in on the matter.

Quad leaves the messy drama of Atlanta behind and jets off to sunny California with Simone and Jill. Meanwhile, Jackie struggles to deal with her ailing father both as a daughter and a doctor. Lisa Nicole celebrates her son’s birthday with a fabulous cooking party but while the bash is in full swing, she drops a bomb that leaves Heavenly and Toya in shock.

Refreshed from her trip to La-La land, Quad refocuses her energy on marketing her doggy fashion line. Meanwhile, Heavenly and her husband are at an impasse when he insists she's spending too much time away from home. Simone makes it clear that it’s her party and can do what she wants to when she disinvites Lisa Nicole.

Determined to show that she’s more than a housewife, Toya follows through with her plan to market her husband’s business. With her eyes set on bigger and better things, Quad has her first pop-up shop to bring Picture Perfect Pup front and center. Meanwhile, Toya reveals a rumor she heard which leaves Simone in tears. 

As Toya looks for locations for her husband’s medical concierge business, she is at odds with him on where to break ground. Meanwhile, Dr. Heavenly’s daughter interns for Lisa Nicole and designs a dress for her mother’s upcoming app release party. At Dr. Jackie’s fitness event, staying in shape is far from everyone’s mind when Lisa Nicole accuses Quad of publicly questioning her husband’s sexuality.  

After months of hard work, Dr. Heavenly is finally ready to launch her dating app, Piq. During her release party, everyone in town stops by, including Atlanta socialite Claudia Jordan. However, Dr. Heavenly’s husband doesn’t love the fact that her new venture will keep his wife busier than ever. Meanwhile, Jill throws a wild Prohibition Party but things get out of control when her husband is accused of disrespecting Dr. Heavenly, and Mariah decides to show up fashionably late to reclaim her seat at the throne. With all the drama surrounding the group, Dr. Simone decides a couples’ trip to the Bahamas will be the best way to put the fractured crew back together.

With the upcoming trip to the Bahamas on the horizon, the ladies have a number of things to settle at home before departing for an island in the sun. The trip starts out on a festive note as the couples are met at the hotel by a band but by dinner, Mariah just can't let go of the past, and Jill and Dr. Heavenly go head to head for round two of their disagreement. 

Although the trip was intended to bring relaxation and reconciliation, the voyage is off to a rocky start with all the ladies reflecting about their relationships with one another. Meanwhile, Dr. Simone tries to get everyone back on track and arranges a medical mission for the less fortunate in order to regroup and focus their attention on helping others.

Couples therapy turns into group therapy as unresolved issues arise between Mariah and some of the ladies. Back in Atlanta, Quad hosts the “Heroes in Healthcare” event bringing most of the women together, however, with tensions still running high from the Bahamas, Dr. Heavenly decides not to attend. At the event, Toya and Mariah exchange words, revealing the real reason why Mariah still holds a grudge against Toya and leading the group to question once and for all whether Mariah belongs in this circle of friends.

The two-part Married to Medicine reunion kicks off with Simone and Toya as they look back at their confrontation from Season 2 and reveal some deep-rooted issues about their childhood. As Quad and Lisa go toe-to-toe over their accusations and legal matters, Heavenly continues to push the women to confess who was to blame over this year's drama. Given light of Jill's recent accusations and arrest, the ladies question whether they treated her fairly. And, bringing her usual spiciness, the Queen Bee Mariah re-enters the Hive for one last showdown. [Part 1 of 2]

Part two of the Married to Medicine reunion sets off the alarm when Mariah quickly realizes she’s the one in the hot seat. It's not all about the ladies this time though as the husbands join the mix and add fuel to the fire. Relationships are put to the test when the conversation turns to Toya and Eugene's inability to communicate. While Lisa's issue with strippers is discussed, it's revealed that Darren isn’t the only husband who likes to indulge in the stripper pond. Plus, the quest begins to see if these ladies can come together again, meanwhile Quad defends her throne to stay in the group. [Part 2 of 2]

This special looks back at lost footage and never-before-seen cast interviews from Season 3.