The news of Curtis’s infidelity sends shockwaves through the group, forcing the husbands and the wives to choose sides. Eugene takes on extra shifts to pay back the IRS, leaving Toya lonely and in need of romance. Quad celebrates the grand opening of Dr. G’s new practice, while Simone struggles to split time between her two houses. Heavenly adjusts to her oldest son away at college, and plans a special night for Jackie and the ladies.

Jackie tries to quietly process Curtis’ infidelity, and scandal hits again when an article exposes more details of the affair. Quad focuses on launching a new career, while Heavenly focuses on helping her daughter’s music career. Meanwhile, Toya throws a competitive “Cook Off” for her birthday, tensions ignite as Heavenly can't control her temper and Simone's struggling marriage reaches a boiling point.

Needing distraction from scandal, Jackie throws a FITNI field day event. New to the group, Dr. Contessa struggles to find the balance between work and family. All of the ladies show up to support Jackie and compete in her event, but the real games begin when Heavenly and Toya disrupt the festivities. Meanwhile, Simone & Cecil seek out professional help as their rocky marriage starts to take its toll on their kids.

To mend their ailing relationship, Quad plans a night of ‘Romance On The Table’ but Dr. G. kills the vibe when he says the wrong thing. Simone confronts Cecil about being a two-faced politician. Meanwhile, Jackie faces the agony of public scrutiny when a patient chimes in on the affair and Toya’s fears about cheating creep into her relationship with Eugene. With things going awry in Atlanta, Simone plans a girl’s getaway to New Orleans, but Simone quickly learns, with this group, “The Big Easy” ain’t so easy. 

The ladies continue their Black Girl Magic trip in the Big Easy. On a swamp tour, Contessa is more concerned with Heavenly snapping back at her than any ‘gator. Back in Atlanta the men enjoy some guy time and cigars. Both Dr. Gregory and Quad are feeling the stress of marriage and seek advice from their friends. Toya promises Jackie and Simone to be nice “all day” but then shocks the group with a surprise guest.

On their last day in New Orleans, the ladies try to salvage the Black Girl Magic experience despite Mariah's return. Simone plans a cultural surprise for the ladies but it hits a snag when Heavenly smells a devil. Led by Jackie, the ladies hold a forgiveness ceremony to take a stab at moving forward. Back in Atlanta, Quad faces a tough homecoming, when forced to confront her marital issues with Dr. G.

Quad, still reeling from her fight with Dr. G, faces some hard choices about the future of her marriage. Toya's mother comes to town and gives her daughter perspective on maintaining a happy marriage. Simone leans on her sister for emotional support. Meanwhile, Jackie asks Cecil's advice on what to do about Curtis. Heavenly continues to try to be a better person but stumbles when she gets into conflict with Mariah. Mariah hosts a Mother's Day brunch for all the ladies, but when Contessa brings her outspoken nanny, Ms. Reneé, the celebration takes a turn for the worse. 

Jackie comes face to face with Curtis for the first time since his infidelity. Simone sees a patient with unique circumstances. In an effort to make up for Ms. Renee’s behavior at Mariah’s party, Contessa turns back the clock and hosts a 90s pool party. But tensions rise, as Simone and Heavenly battle with Mariah, leaving Toya trying to keep the peace.

The 90's pool party continues with a bang. Contessa struggles balancing work life and family after Ms. Reneé sudden departure. Jackie and Curtis continue their courting with a 2nd date. Heavenly takes Alaura to see a vocal coach to the stars. Simone is blindsided by Cecil’s investment in a business venture. Toya tries to seduce Eugene and bring the sexy back into their life. Quad and Greg attempt to solve their problems with a marital focus group, but facing the hard truths leaves them both struggling to move forward.

Jackie meets Curtis for the first time in public, and he gives her a surprise invitation. Maintaining a good work/life balance becomes too much for Contessa as she and Scott try to adjust. Just as they’re getting closer to paying off their IRS debt, Toya and Eugene are hit with a new financial shock. Quad gets a spot on local TV to demo her new cookbook, but Greg isn’t there to support her. Simone helps Cecil launch his new app with a big party, but escalating tension between Mariah and Heavenly threatens to turn the big event into a big fiasco.

Still reeling from drama at the app party, Mariah must decide if she wants to accept an offer from Heavenly. Jackie is stunned when Curtis ambushes her on the way to Barbados, and his arrival sends shockwaves through the group, leading to an awkward encounter with Toya. Later, tensions rise during a first night Newlywed game, as Quad and Greg find all of their problems reaching a boiling point.

Heavenly takes Damon on an emotional journey, leading to revelations from his past. All the couples get an eye-opening group sex therapy session, where Jackie must come face to face with the state of her marriage. During a medical mission to help island locals, Eugene gets a major health scare. Later, there’s trouble on the high seas as a luxury yacht ride heads into stormy waters. Mariah and Simone confront Quad on her selfish behavior. Can the group survive or will it be woman overboard?

After a turbulent yacht expedition, Heavenly puts all her energy into leading Couples Therapy. But when she refuses to share any of her own problems and asks questions that push everyone’s buttons, a revolt erupts on the beach! Jackie finally breaks down emotionally and allows herself to be vulnerable with Curtis; Simone and Cecil’s tensions boil over, while the drama between Quad and Greg reaches a new level. Mariah shares a shocking revelation about her own marriage.

Home from Barbados, Heavenly decides to throw a DNA reveal party to make up for her failed couple’s therapy. Jackie lets Curtis move back into the house, but with a surprise stipulation. Quad and Greg meet with their marital focus group to, but wind up in worse shape than before. Contessa makes an emotional and life-changing decision. Later, at the DNA party, Quad and Toya fight, causing Eugene to use a hot-button word that sends everyone into a tailspin.

Toya and Eugene celebrate paying off their tax debt by throwing an In the Black Party. Simone and Cecil send their eldest son Miles off to college. Jackie and Curtis go through some growing pains. Contessa has some unfinished business with Eugene. Things go from bad to worse for Quad and Greg in their crumbling marriage.

Host Andy Cohen reflects on some of the seasons biggest moments as the ladies of medicine come together in part one of the explosive three-part Married to Medicine Reunion. Toya is put on the hot seat about her sex life; Contessa defends her nanny against an onslaught of attacks; Mariah dishes her grievances with Heavenly, telling her what she really thinks of her, leading to a dramatic confrontation; Simone reveals shocking new information about her marriage. [Part 1 of 3]

The reunion continues as Andy welcomes the husbands to tell their side of the story. Cecil explains himself and makes surprising claims about another woman; Eugene defends himself against Toya's sex rating; Curtis answers for his misdeeds, but has harsh words for Eugene. Later, Quad and Greg try to work through their issues, but a startling new revelation from Greg threatens to tear their marriage further apart. [Part 2 of 3]

The reunion concludes in part three, as the group deals with the fallout from Greg's scandalous revelation. Seeing another marriage falling apart, the group rallies around Simone and Cecil, imploring them to work it out. Will their pleas be heard or will they fall on deaf ears? [Part 3 of 3]