The ladies of medicine are back and the lines in the sand have been drawn. Dr. Heavenly and Dr. Jackie shake up the group with their Open and Honest podcast. Toya and Eugene struggle to finish construction on their dream home. Dr. Contessa’s traveling back and forth causes Scott to put on his single dad hat. Dr. Simone is happy to have her whole family back under one roof. The ladies try to come together at Heavenly’s Hollywood Glam party, but the night quickly turns into chaos.

Contessa’s pursuit of higher education continues to drive a wedge between her and Scott. Toya tries to put on a brave face and be there for her family after a devastating loss. Quad updates the ladies on her divorce. As the Twitter war between Simone and Heavenly comes to a fever pitch, Jackie throws an "Emergen-Tea" party to set everything right. Will the tea be served or spilled?

Simone and Quad struggle to repair their friendship, but a breaking point may be near. Toya and her family struggle to heal from her miscarriage. Dr. Heavenly vents to Damon that Alaura is growing up too fast, but Simone wants her boys to grow up and clean up. Jackie and Simone hatch a surprise dinner with Heavenly and Mariah to work out their issues, but will Heavenly and Mariah run for the door when they discover the ambush?

Jackie and Curtis have big plans to tear down and rebuild their home but will the budget fit their dreams? Contessa realizes that that being away in Nashville is making her a distant memory to her family. Simone's friend Buffie throws a Fab and Frugal party where things get ugly when Toya is put on the spot about past money woes. Later, Toya throws a paint and sip for her birthday with a surprise twist that shocks her friends.

Toya shocks the ladies with her idea of an art class. Heavenly decides not to tell Damon about Toya’s explicit birthday party. While Simone and Cecil give the boys a safe sex talk, Jackie does some sexual research for an exciting new project. As Toya and Eugene move into their new house, Contessa surprises Scott with some big moves of her own.

Hoping to get the ladies’ friendships back on track, Jackie invites the group to Savannah for a good old-fashioned girls’ trip. Feeling called out by Damon, Heavenly takes it out on Toya. Mariah goes after the whole group for perpetuating lies against her. By the end of a disastrous dinner, Jackie’s “friendship revival” is clearly on life support. Can she save this trip before it flat lines?

Any progress made during Revival Weekend in Savannah comes to a screeching halt after Mariah's meltdown on the bus. Dr. Jackie reaches her breaking point when she realizes that there are some problems she just can't fix. Contessa ponders Jackie's advice to pursue couples' counseling for herself and Scott. Mariah brings the receipts and the drug test results to prove Quad wrong, but do the rest of the ladies even want to know the truth?

Jackie butts heads with Curtis over the rising costs of their home renovations. Contessa gives her dad a new smile courtesy of Dr. Heavenly. Simone and Cecil give Miles a wake-up call about his future. Quad celebrates her birthday and the launch of her new cookbook, but since she’s not on the guest list, Mariah celebrates Ramadan with her family. But when Quad shades her friends in her thank-you speech, will the festivities flat line?

Quad loses her mind when she allows Heavenly to set her up on a blind date. Dr. Jackie piles on her to-do list by renovating a new office. An overwhelmed Contessa throws a huge carnival birthday for her kids, hoping to make up for her mommy guilt. Buffie comes to Simone for help when she discovers a lump in her breast. 

Toya and Eugene invite Simone and Cecil over to tour their new forever home. Contessa and Scott face hard truths about their relationship in their first therapy session. Jackie hosts a party to launch her book “The Queen V” and outs some very personal information about Buffie. Later, everyone heads to Cabo for their couple's trip and have a boogie-down battle for the chance to win a penthouse suite.

Buffie breaks her silence with Jackie for talking about her infertility, but Jackie hits back hard. Toya has a meltdown when the mini bus breaks down, forcing Simone and Cecil scramble to come up with a new couple's activity. Can they save the trip or will everything go loco, Mexican Messy Boots style?   

The couples' trip to Cabo continues. Contessa and Scott continue to clash, putting their relationship on the brink. Jackie apologizes to Buffie for their fight the night before, but Buffie's far from over it. When the guys and the ladies have separate nights out, Quad gets a special girls night and Damon winds up in the doghouse with Heavenly.

In Cabo San Lucas, the group participates in a good old fashioned wife swap - with games on the beach! Heavenly's anger at Damon going to the strip club boils over. Contessa and Scott put on a brave face for the group, but their marriage issues are bubbling under the surface. Back in Atlanta, Quad's divorce proceedings inch closer to the finish line.

Back from Cabo, Quad celebrates her new found singledom with pal Cynthia Bailey, Toya starts planning her big housewarming for her new forever home, and Scott and Contessa have a major breakthrough in therapy. When Buffie throws a spa day to recharge the friendships, the last thing on the agenda is rest and relaxation.

As Jackie and Curtis begin renovations on their new home, Toya plans the ultimate housewarming party. Contessa and Scott finally come together on her decision to return to school in Nashville, while Heavenly battles with her decision to trust Alaura. Toya's Arabian Nights Housewarming party hits a snag when Buffie breaks down, Jackie steps away from the ladies, and Contessa and Mariah break the peace of Toya’s two-story closet in an epic showdown.

Host Andy Cohen reflects on some of the seasons biggest moments as the ladies of medicine come together in part one of the explosive “Married to Medicine” Reunion. Quad discusses her current relationship status, while Simone surprises everyone with new information about Dr. G. Buffie confronts Dr. Jackie causing Heavenly to leap to her defense. [Part 1 of 3]

The reunion continues as Andy welcomes the husbands to tell their side of the story. The ladies talk about their favorite shady moments from the season. Mariah discusses the allegations brought up against her. Dr. Simone and Dr. Jackie shock everyone when they reveal a rift in their friendship. [Part 2 of 3]

The reunion concludes as Andy is joined by all the couples. Damon comes face to face with his actions in Cabo. Aydin and Mariah defend themselves. Toya opens up about her past love, upsetting Eugene. Contessa speaks her truth. After hashing out old and new issues, will the ladies be able to come together as a group again? [Part 3 of 3]