Grey's Anatomy backdrop
Drama

The Best Episodes of Grey's Anatomy Season 4

Every episode of Grey's Anatomy Season 4 ranked from best to worst. Discover the Best Episodes of Grey's Anatomy Season 4!

Binge this in 12h 11m•Peaking at 8.6/10

Follows the personal and professional lives of a group of doctors at Seattle's Grey Sloan Memorial Hospital.

Airs on
ABC
BestEpisodes
WorstEpisodes
BestSeasons
AllEpisodes

Seasons23

All1234567891011121314151617181920212223

Episode Rankings

  1. #1 Fan Favorite
    Grey's Anatomy Season 4 Episode 16 - Freedom
    8.6/10(1832 votes)

    S4:E16

    A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.

    Director:Rob Corn
    Writer:Shonda Rhimes

    Be the first to start the conversation for this episode

  2. Grey's Anatomy Season 4 Episode 9 - Crash Into Me (1)
    8.5/10(1658 votes)

    S4:E9

    An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.

    Director:Michael Grossman
    Writers:Krista Vernoff, Shonda Rhimes

    Be the first to start the conversation for this episode

  3. Grey's Anatomy Season 4 Episode 10 - Crash Into Me (2)
    8.4/10(1574 votes)

    S4:E10

    Meredith works furiously to save a paramedic trapped in an ambulance; Lexie holds the life of a patient in her hands; Derek must rely on a nurse to save a patient; Bailey struggles to balance her personal life with her work.

    Director:Jessica Yu
    Writers:Krista Vernoff, Shonda Rhimes

    Be the first to start the conversation for this episode

  4. Grey's Anatomy Season 4 Episode 13 - Piece of My Heart
    8.1/10(1435 votes)

    S4:E13

    Addison visits Seattle Grace because they need skills that only she has. Rebecca/Ava returns with news for Alex. Meredith and Derek's clinical trial experiences one or two developments.

    Director:Mark Tinker
    Writer:Stacy McKee

    Be the first to start the conversation for this episode

  5. Grey's Anatomy Season 4 Episode 1 - A Change Is Gonna Come
    8.0/10(1683 votes)

    S4:E1

    Entering their first year as residents, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new interns are George, forced to repeat his internship after failing his exams, and Lexie Grey, Meredith's half-sister. Another two new interns will be introduced in this season premiere. And they'll have their hands full when a three-car accident sends multiple casualties pouring into Seattle Grace. Some of the doctors need to deal with new stressed out interns. A young boy brings his bleeding deer to the hospital in the hope a doctor will save her.

    Directors:Michael Grossman, Rob Corn
    Writer:Shonda Rhimes

    Be the first to start the conversation for this episode

  6. Grey's Anatomy Season 4 Episode 12 - Where The Wild Things Are
    8.0/10(1430 votes)

    S4:E12

    Time has passed but not much has changed. Sexual angst still runs rampant in the halls of Seattle Grace. Derek and Rose have been dating and Meredith has noticed the activities of her current off-again ex-boyfriend. The doctor's are in the midst of a competition.

    Director:Rob Corn
    Writer:Zoanne Clack

    Be the first to start the conversation for this episode

    7. Trending NowTRENDING NOW

    The 20 BEST Episodes of Grey's Anatomy

    READ
  7. Grey's Anatomy Season 4 Episode 14 - The Becoming
    8.0/10(1640 votes)

    S4:E14

    The clinical trial continues to make progress. The anti-McSteamy club creates new initiatives but that isn't enough to stop one woman from spending time with him. Christina is affected by Burke's career developments.

    Director:Julie Anne Robinson
    Writer:Joan Rater

    Be the first to start the conversation for this episode

  8. Grey's Anatomy Season 4 Episode 15 - Losing My Mind
    8.0/10(1480 votes)

    S4:E15

    Dr. Wyatt refuses to let Meredith give up on therapy. Alex learns something else about Rebecca. The Chief wants Erica to perform a daring surgery. Christina continues to act strangely.

    Director:James Frawley
    Writer:Debora Cahn

    Be the first to start the conversation for this episode

  9. Grey's Anatomy Season 4 Episode 3 - Let the Truth Sting
    7.9/10(1494 votes)

    S4:E3

    The doctors meet the world's oldest intern. Marcy brings in her son Henry because she finds his change in behavior suspicious. A patient named Connie may lose her vocal chords unless Mark and Richard can perform a radical new surgery. George impresses the other interns at work but at home he is trying to deal with his guilt about having sex with Izzie.

    Director:Daniel Minahan
    Writer:Mark Wilding

    Be the first to start the conversation for this episode

  10. Grey's Anatomy Season 4 Episode 4 - The Heart of the Matter
    7.9/10(1522 votes)

    S4:E4

    A face familiar to one of the year-twos shows up and dredges up issues that were never really dealt with. A teen soccer player needs counseling because of his father and surgery for an injury he sustained while playing the game. Another patient's, named Courtney, finds out that her cancer is back.

    Director:Randall Zisk
    Writer:Allan Heinberg

    Be the first to start the conversation for this episode

  11. Grey's Anatomy Season 4 Episode 8 - Forever Young
    7.9/10(1499 votes)

    S4:E8

    There has been a bus crash and the patients are in the ER. Meredith and Derek's relationship gets more complicated when he dates a fellow doctor. Meredith's dad goes to visit her at the hospital.

    Directors:Rob Corn, Tom Verica
    Writer:Mark Wilding

    Be the first to start the conversation for this episode

  12. Grey's Anatomy Season 4 Episode 11 - Lay Your Hands on Me
    7.9/10(1474 votes)

    S4:E11

    George has a surprise visitor. Bailey's family is falling apart. Derek sorts through what kissing Rose means. Meredith discovers something that doesn't inspire hope or happiness in her. Alex treats a faith healer.

    Director:John Terlesky
    Writer:Allan Heinberg

    Be the first to start the conversation for this episode

  13. Grey's Anatomy Season 4 Episode 5 - Haunt You Every Day
    7.8/10(1483 votes)

    S4:E5

    It's Halloween at Seattle Grace! There may be jokes, pranks, and/or scare tactics. Some of the women form a club based on an experience they all share. A man volunteers for what most of the doctors believe is an unnecessary surgery. One of the patients is in the hospital because they tried to carve a pumpkin in an unconventional manner.

    Director:Bethany Rooney
    Writer:Krista Vernoff

    Be the first to start the conversation for this episode

  14. Grey's Anatomy Season 4 Episode 6 - Kung Fu Fighting
    7.8/10(1418 votes)

    S4:E6

    A patient comes to the ER with a dream and a condition which may prevent him form realizing it. Two patients are competing to win something big. One of them convinces an intern to take their place.

    Director:Tom Verica
    Writer:Stacy McKee

    Be the first to start the conversation for this episode

  15. Grey's Anatomy Season 4 Episode 2 - Love/Addiction
    7.7/10(1473 votes)

    S4:E2

    A patient is in the hospital because they fell asleep in a hazardous situation. A patient's home laboratory blew up in an apartment building and the victims flood the hospital. Alex investigates the cause of the incident by talking to a really old guy who lived in the building. Jane Burke shows up to deal with what her son left behind. Lexie tries to talk to Meredith. Callie is overwhelmed by her new position while Bailey is searching for things to do.

    Director:James Frawley
    Writer:Debora Cahn

    Be the first to start the conversation for this episode

  16. Grey's Anatomy Season 4 Episode 7 - Physical Attraction, Chemical Reaction
    7.7/10(1430 votes)

    S4:E7

    Izzie and George's new-founded relationship results in them having bad sex. Callie's Chief Resident position is taken away from her, and Bailey is the humble replacement. Meredith can barely handle it with Lexie anymore.

    Director:Jeff Melman
    Writer:Joan Rater

    Be the first to start the conversation for this episode

Season 4 Ratings Summary

"Freedom" is the best rated episode of "Grey's Anatomy" season 4. It scored 8.6/10 based on 1832 votes. Directed by Rob Corn and written by Shonda Rhimes, it aired on 5/22/2008. This episode is rated 0.1 points higher than the second-best, "Crash Into Me (1)".