Grey's Anatomy backdrop
Drama

The Best Episodes of Grey's Anatomy Season 21

Every episode of Grey's Anatomy Season 21 ranked from best to worst. Discover the Best Episodes of Grey's Anatomy Season 21!

Binge this in 13h 7m•Peaking at 8.1/10

Follows the personal and professional lives of a group of doctors at Seattle's Grey Sloan Memorial Hospital.

Airs on
ABC
BestEpisodes
WorstEpisodes
BestSeasons
AllEpisodes

Seasons23

All1234567891011121314151617181920212223

Episode Rankings

  1. #1 Fan Favorite
    Grey's Anatomy Season 21 Episode 7 - If You Leave
    8.1/10(463 votes)

    S21:E7

    The doctors at Grey Sloan must put aside their emotions under intense circumstances. Levi asks James a shocking question that could impact their future.

    Director:Allison Liddi-Brown
    Writer:Tameson Duffy

    Be the first to start the conversation for this episode

  2. Grey's Anatomy Season 21 Episode 18 - How Do I Live
    8.1/10(489 votes)

    S21:E18

    While the interns are excited to transition to second-year residency, an ordinary day at Grey Sloan takes an unexpected turn when a medical emergency unfolds in the operating room, endangering lives inside the hospital.

    Director:Debbie Allen
    Writer:Meg Marinis

    Be the first to start the conversation for this episode

  3. Grey's Anatomy Season 21 Episode 17 - Love You Like a Love Song
    7.8/10(399 votes)

    S21:E17

    Jo and Link's wedding day arrives, along with some visitors. Meanwhile, Teddy and Owen are met with a familiar face seeking treatment, and Lucas disagrees with Simone on how to approach a patient's worsened condition.

    Director:Kevin McKidd
    Writers:Julie Wong, Michelle Lirtzman

    Be the first to start the conversation for this episode

  4. Grey's Anatomy Season 21 Episode 2 - Take Me to Church
    7.5/10(430 votes)

    S21:E2

    Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support. Richard, Winston and Lucas spend the day outside of the hospital, and Blue deals with a relationship from his past. Levi meets the new hospital chaplain.

    Director:Kevin McKidd
    Writer:Michelle Lirtzman

    Be the first to start the conversation for this episode

  5. Grey's Anatomy Season 21 Episode 4 - This One's for the Girls
    7.5/10(408 votes)

    S21:E4

    Mika struggles with a life-altering personal matter. Meanwhile, Bailey and Ben navigate their personal and professional roles, while Levi finds a connection in an unlikely place. Jo and Link get surprising news.

    Director:Debbie Allen
    Writer:Briana Belser

    Be the first to start the conversation for this episode

  6. Grey's Anatomy Season 21 Episode 12 - Ridin' Solo
    7.5/10(377 votes)

    S21:E12

    Meredith and Amelia prepare a funding proposal for their Alzheimer’s research. Meanwhile, Teddy and Owen hit a breaking point in their marriage, while Jules has an awkward encounter with Dr. Beltran.

    Director:Morenike Joela Evans
    Writer:Sandra Hamada

    Be the first to start the conversation for this episode

    7. Trending NowTRENDING NOW

    The 20 BEST Episodes of Grey's Anatomy

    READ
  7. Grey's Anatomy Season 21 Episode 16 - Papa Was a Rollin' Stone
    7.5/10(369 votes)

    S21:E16

    Amelia undertakes a high-risk brain surgery on a young patient, while Winston and Jules disagree over how to handle their trauma patient's family. Jo and Link struggle with wedding planning.

    Director:Chandra Wilson
    Writer:Jess Righthand

    Be the first to start the conversation for this episode

  8. Grey's Anatomy Season 21 Episode 5 - You Make My Heart Explode
    7.4/10(403 votes)

    S21:E5

    During a high-stress day at Grey Sloan Memorial, the fates of a patient in critical condition and a helicopter-bound medical team hang in the balance. Teddy and Owen work on their marriage, while Bailey, Blue and Link treat a hospital employee.

    Director:Vanessa Parise
    Writer:Zoanne Clack

    Be the first to start the conversation for this episode

  9. Grey's Anatomy Season 21 Episode 6 - Night Moves
    7.4/10(427 votes)

    S21:E6

    Teddy and Owen plan a date night that gets derailed in more ways than one, while Jo struggles to do it all at home. Mika adds more to her plate to make up for taking time off to be with her sister, and Levi is faced with a monumental decision.

    Director:Bille Woodruff
    Writer:Jase Miles-Perez

    Be the first to start the conversation for this episode

  10. Grey's Anatomy Season 21 Episode 3 - I Can See Clearly Now
    7.3/10(408 votes)

    S21:E3

    Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant. Teddy offers Amelia a new opportunity, and Ben's interview doesn't go as planned. Meredith's secret causes tension with Richard.

    Director:Victoria Mahoney
    Writer:Mark Driscoll

    Be the first to start the conversation for this episode

  11. Grey's Anatomy Season 21 Episode 8 - Drop It Like It's Hot
    7.3/10(427 votes)

    S21:E8

    In the midst of a deadly heat wave, the team at Grey Sloan struggles to keep up with an overwhelming amount of patients. Amelia and Winston face a challenging surgery, while Jo and Lucas run an errand for the hospital that takes an unexpected turn.

    Director:Kevin McKidd
    Writer:Jess Righthand

    Be the first to start the conversation for this episode

  12. Grey's Anatomy Season 21 Episode 9 - Hit the Floor
    7.3/10(380 votes)

    S21:E9

    The aftermath of the convenience store shooting brings chaos to Grey Sloan. Ben hits a wall with his new emergency preparedness plan. Romantic tensions surface for Owen, while Amelia and Winston disagree over the surgical plan for a young patient.

    Director:Linda Klein
    Writer:Jamie Denbo

    Be the first to start the conversation for this episode

  13. Grey's Anatomy Season 21 Episode 10 - Jump (For My Love)
    7.3/10(375 votes)

    S21:E10

    Meredith and Nick return to Grey Sloan to treat a liver transplant patient. Meanwhile, Bailey hosts an intern retreat at her home, and Winston and Ben aid an unexpected crash victim.

    Director:Jesse Williams
    Writer:Julie Wong

    Be the first to start the conversation for this episode

  14. Grey's Anatomy Season 21 Episode 13 - Don't You (Forget About Me)
    7.3/10(375 votes)

    S21:E13

    Amelia and Simone attempt to perform a high-stakes and groundbreaking brain surgery. Teddy and Bailey attend a medical conference and run into Dr. Cass Beckman. Meanwhile, Jo struggles with her irritation toward a younger OB-GYN.

    Director:Kevin McKidd
    Writers:Julie Wong, Michelle Lirtzman

    Be the first to start the conversation for this episode

  15. Grey's Anatomy Season 21 Episode 14 - Love in the Ice Age
    7.3/10(366 votes)

    S21:E14

    Bailey welcomes a renowned surgeon, whom she greatly admires, to Grey Sloan to help on a challenging case. Meanwhile, Teddy, Owen, Jules and Ben team up to save the life of a patient who has been impaled by an ice pick.

    Director:Morenike Joela Evans
    Writer:Kingsley Ume

    Be the first to start the conversation for this episode

  16. Grey's Anatomy Season 21 Episode 1 - If Walls Could Talk
    7.2/10(490 votes)

    S21:E1

    After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research. Accidents at a climate change protest bring unique cases to the hospital, and Bailey encounters a blast from the past.

    Director:Debbie Allen
    Writer:Meg Marinis

    Be the first to start the conversation for this episode

  17. Grey's Anatomy Season 21 Episode 11 - I Still Haven't Found What I'm Looking For
    7.2/10(382 votes)

    S21:E11

    Following a difficult case, the team faces the complexities of medical ethics. Meanwhile, Bailey continues to navigate her working relationship with Ben, while a group of college students on a scavenger hunt causes chaos around the hospital.

    Director:Kim Raver
    Writer:Carol Brown

    Be the first to start the conversation for this episode

  18. Grey's Anatomy Season 21 Episode 15 - Bust Your Windows
    7.2/10(367 votes)

    S21:E15

    A window washer’s platform crashes through a hospital window, testing the Grey Sloan team’s limits. Meanwhile, Blue and Simone clash over their living arrangements, and Lucas strives to impress Catherine while on her service.

    Director:Lisa Leone
    Writer:Scott D. Brown

    Be the first to start the conversation for this episode

Season 21 Ratings Summary

"If You Leave" is the best rated episode of "Grey's Anatomy" season 21. It scored 8.1/10 based on 463 votes. Directed by Allison Liddi-Brown and written by Tameson Duffy, it aired on 11/14/2024. This episode is rated 0.0 points higher than the second-best, "How Do I Live".