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The Best Episodes of Grey's Anatomy Season 2

Every episode of Grey's Anatomy Season 2 ranked from best to worst. Discover the Best Episodes of Grey's Anatomy Season 2!

Binge this in 17h 55m•Peaking at 9.4/10

Follows the personal and professional lives of a group of doctors at Seattle's Grey Sloan Memorial Hospital.

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Episode Rankings

  1. #1 Fan Favorite
    Grey's Anatomy Season 2 Episode 16 - It's the End of the World
    9.4/10(3740 votes)

    S2:E16

    An explosive case arrives at the O.R. that might endanger all the lives of the people working there, which leads Dr. Burke to declare a "Code Black" for the hospital. Bailey worries where her husband is as she is in labor. Also Izzie and Alex may be creating some heat.

    Director:Peter Horton
    Writer:Shonda Rhimes

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  2. Grey's Anatomy Season 2 Episode 17 - As We Know It
    9.4/10(3628 votes)

    S2:E17

    Derek is still operating when he finds out about Meredith's current situation. Meredith is freaking out about her situation. Webber and Bailey are dealing with medical health issues. Cristina and Izzie have their own issues to deal with because of Meredith's situation. Addison freaks out when George tries to find a solution to Bailey's impromtu postponement. Overall, Seattle Grace Hospital is still under code black and the situation is getting worse.

    Director:Peter Horton
    Writer:Shonda Rhimes

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  3. Grey's Anatomy Season 2 Episode 27 - Losing My Religion
    9.2/10(2967 votes)

    S2:E27

    This episode is the second part of a two-hour season finale. Richard tries to get information from Addison about a family member's condition. Callie and George have a talk about his feelings. Meredith and Derek have a talk about Doc.

    Director:Mark Tinker
    Writer:Shonda Rhimes

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  4. Grey's Anatomy Season 2 Episode 6 - Into You Like a Train
    9.0/10(2622 votes)

    S2:E6

    Train Wreck victims come to Seattle Grace and all staff gets called in. Everyone deals with really weird cases. Except Addison and Izzie. They work with a woman who is pregnant.

    Director:Jeff Melman
    Writer:Krista Vernoff

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  5. Grey's Anatomy Season 2 Episode 25 - 17 Seconds
    9.0/10(2265 votes)

    S2:E25

    George and Derek work together, Denny still doesn't have a heart, and Meredith gets paired with Callie. A 12-week pregnant girl dies in the O.R. and her parents try to keep the baby alive. This causes tension between Derek and Addison. One doctor's overreaction unites two bickering patients. Finn is still treating Doc for medical problems.

    Director:Daniel Minahan
    Writer:Mark Wilding

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  6. Grey's Anatomy Season 2 Episode 26 - Deterioration of the Fight or Flight Response
    9.0/10(2255 votes)

    S2:E26

    Denny needs a heart or else. Izzie and George go crazy trying to get him one. Derek has the life of a friend in his hands as he operates on Burke who has been shot. Burke cannot operate on Denny after Denny's heart stopped and now Denny is in a dire condition. Cristina gets put in charge of the ER and she is worried about Burke.

    Director:Rob Corn
    Writer:Joan Rater

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  7. Grey's Anatomy Season 2 Episode 3 - Make Me Lose Control
    8.6/10(2084 votes)

    S2:E3

    Cristina and Meredith try to figure out if Cristina should tell Burke that she's pregnant right before Cristina faces an emergency. Alex and Izzie get closer while Meredith's mother gets too close.

    Director:Adam Davidson
    Writer:Krista Vernoff

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  8. Grey's Anatomy Season 2 Episode 5 - Bring the Pain
    8.5/10(1988 votes)

    S2:E5

    Cristina goes right back to working right after being discharged. Izzie isn't talking to Alex. Derek and Meredith treat a patient. George and Alex get stuck in an elevator.

    Director:Mark Tinker
    Writer:Shonda Rhimes

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  9. Grey's Anatomy Season 2 Episode 24 - Damage Case
    8.4/10(1800 votes)

    S2:E24

    The staff attends to an intern from another hospital who has short-term memory loss. This intern, named Marshall, also has caused a car accident that involved a married couple, their unborn baby and the woman's parents who the staff are also treating. The pregnant woman is named Melanie and she will die but her baby may survive. One of the female interns meets up with a woman from her past who is planning on having a family of her own. Cristina is in a good mood although Alex, Izzie, George, and Meredith are having problems but in the meantime Burke hasn't forgiven Cristina for her late night faux pas. Meredith and Izzie are making fun of Callie's household habits and George and Callie are having a fight because of George's roommates. Addison is continuing to own Alex and he's upset about it. Denny has an outburst at Izzie and Derek has an outburst at Meredith.

    Director:Tony Goldwyn
    Writer:Mimi Schmir

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  10. Grey's Anatomy Season 2 Episode 1 - Raindrops Keep Falling on My Head
    8.3/10(2074 votes)

    S2:E1

    Picks up where the last episode left off. Meredith attempts to work with Addison Shepard. George is pimped out to relay the hospital gossip back to Webber. Meredith and Cristina relate at Emerald City Bar about what dating their respective attendings is like. Cristina ponders her relationship with Burke while trying to make a decision. Meredith is devastated by the latest blow to her love life. Meanwhile, Joe the bartender collapses.

    Director:Peter Horton
    Writer:Stacy McKee

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  11. Grey's Anatomy Season 2 Episode 4 - Deny, Deny, Deny
    8.3/10(1956 votes)

    S2:E4

    As Cristina tries to recover, she proves to be a very difficult patient, and a visit from her mother doesn't improve her demeanor any. And Meredith's mother, Dr. Ellis Grey, has the hospital staff running in circles.

    Director:Wendey Stanzler
    Writer:Zoanne Clack

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  12. Grey's Anatomy Season 2 Episode 9 - Thanks for the Memories
    8.3/10(1846 votes)

    S2:E9

    It's Thanksgiving at Seattle Grace Hospital but the holiday's festivites are less than in order. Meredith and Derek try to counsel a family after their relative has had a seriously traumatic accident.

    Director:Michael Dinner
    Writer:Shonda Rhimes

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  13. Grey's Anatomy Season 2 Episode 15 - Break on Through
    8.3/10(1813 votes)

    S2:E15

    All the nurses at Seattle Grace Hospital go on strike, leaving the doctors to fend for themselves. George refuses to cross the picket line and finally joins the nurses on their strike while Alex, Cristina, Izzie and Meredith meets Bailey's stand-in: Dr. Cindy Aaron, the complete opposite of Miranda Bailey. Izzie agrees to work on a difficult pregnancy case with Addison, while Cristina and Alex are in the pit attending to a young married woman with a real bad case of rash. Meredith happens on an old woman that she needs to intubate and then learns she was DNR.

    Director:David Paymer
    Writer:Zoanne Clack

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  14. Grey's Anatomy Season 2 Episode 18 - Yesterday
    8.3/10(1832 votes)

    S2:E18

    Derek and Addison's relationship is rocked to the core when a former friend comes to Seattle Grace and his presence promises to shake things up for a few members of the staff. Burke and Cristina's relationship is affected when one of her secrets is outted. Alex and Izzie are having similar reactions to their closet scenes during the Code Black crisis. On top of this a cocky doctor shows up to piss Derek off in all kinds of ways. A patient is suffering from constant orgasms and her condition sparks interesting conversations among the staff. George is trying to figure out how to get Meredith to see him as more than just a housemate. Another patient, that Derek is treating, is dealing with a rare disorder and needs his parents support and understanding. Burke has a patient who inspires him to talk to Meredith and Cristina about doing what they say they will. Meanwhile, Meredith learns more about her family (in fact maybe more than she may have wanted to know) through her parents.

    Director:Rob Corn
    Writer:Unknown

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  15. Grey's Anatomy Season 2 Episode 7 - Something to Talk About
    8.1/10(1783 votes)

    S2:E7

    Cristina, Izzie and Meredith take care of Shane, a man who appears to be crazy and claims that he is pregnant. Shane's case induces a spreading fascination among the staff. George relates to a patient's husband.

    Director:Adam Davidson
    Writer:Stacy McKee

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  16. Grey's Anatomy Season 2 Episode 11 - Owner of a Lonely Heart
    8.1/10(1727 votes)

    S2:E11

    Cristina Yang has little sympathy for Constance Ferguson (special guest star Rosanna Arquette), a prison inmate who jeopardizes her health just to get out of solitary confinement. Meanwhile the interns all keep careful watch on the family of premature quintuplets with a variety of serious health challenges, Izzie's anger at Alex reaches boiling point, and Dr. Addison Shepherd decides to teach Izzie a very painful lesson.

    Directors:Daniel Minahan, Chandra Wilson
    Writer:Mark Wilding

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  17. Grey's Anatomy Season 2 Episode 12 - Grandma Got Run Over By a Reindeer
    8.1/10(1755 votes)

    S2:E12

    The holiday season has started but not everyone is in a festive mood. This is Alex's last day in the hospital unless he passes his boards practical exam the next day, thus everyone helps him to review so that he succeeds. However, Izzie is not happy about the others helping him and Meredith has to remind her of the true spirit of the Christmas holiday. Justin is in need of a new heart. One is available but he does not want it because he does not believe Santa gave it to him as his mother said. Cristina and Burke, both handling Justin's case, have opposing views on the matter due to their different stances on religion. Despite a reconciliation with his wife, Derek isn't in a festive mood. George has a simple case of a woman who has a bleeding ulcer, he realizes that the ulcer is caused by her entourage but fails to keep them away, with the consequence that it perforates.

    Director:Peter Horton
    Writer:Krista Vernoff

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  18. Grey's Anatomy Season 2 Episode 13 - Begin the Begin
    8.1/10(1816 votes)

    S2:E13

    Cristina is bothered by a new year's mandatory work limit. Izzie patient, Denny Duquette, wants two things: 1. a heart transplant, 2. Izzie. Addison detests Derek's trailer, Derek visits Meredith's mom, George treats a young teen hermaphrodite frustrated by her pre-pubescence. Other news includes patients doing uncanny things and relationship havoc being wrecked between the doctors, as per usual.

    Director:Jessica Yu
    Writer:Kip Koenig

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  19. Grey's Anatomy Season 2 Episode 21 - Superstition
    8.1/10(1679 votes)

    S2:E21

    After a series of deaths at the hospital some of the staff become very superstitious. Izzie worries about Denny and gets confronted by Alex. A patient with OCD drives Cristina crazy. Derek and Addison discuss their relationships with Meredith. Richard treats a friend from 17 years ago who reveals a secret about a dark time in his past that involves Ellis. George gets an earful about the women he's not talking to. Burke and Cristina argue about kicking George out.

    Director:Tricia Brock
    Writer:James D. Parriott

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  20. Grey's Anatomy Season 2 Episode 22 - The Name of the Game
    8.1/10(1693 votes)

    S2:E22

    Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew's surgery because she's worried that her coworkers won't recognize her Nazi-status now that she's a mother. Addison's patient has an unborn baby with medical issues. After Alex fails to bite his tongue when a terminal patient routinely lies to her daughter about her health he gets a lesson in bedside manners from Burke. George also begins to overstay his welcome at Burke's apartment after Callie visits him. Meredith has more confusing and uncomfortable encounters with members of her family. One of the female doctors meets a veterinarian named Finn. Izzie flirts with Denny and they play more naughty-Scrabble. Meredith, Derek, and Addison sarcastically take another small stab at their friendships.

    Director:Seith Mann
    Writers:Shonda Rhimes, Blythe Robe

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  21. Grey's Anatomy Season 2 Episode 2 - Enough Is Enough
    8.0/10(1910 votes)

    S2:E2

    There's tension between Meredith and Addison. We find out why Derek and Addison aren't together. Bailey puts George on an impossible case. The rest of the interns operate on a family that was just in a car accident.

    Director:Peter Horton
    Writer:James D. Parriott

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  22. Grey's Anatomy Season 2 Episode 10 - Much Too Much
    8.0/10(1769 votes)

    S2:E10

    Dorie Russell is waiting for quintuplets, all 5 girls. Her husband seems more concerned than she is but she is set to bring her babies to their term of 36 weeks. All the departments are on call for the quintuplets as three of them have developped problems of different kinds. Meredith last night's stand shows up at the hospital with priapism and they need to call Derek Sheperd for a consult which puts Meredith in a very embarassing position. Alex and Derek must take care of a patient who has a tumor inducing thirst as a side effect. On the love side, Alex and Izzie are having some slight sexual problems, while Meredith goes on adding one night stands and Cristina is thrown off course by being "keyed."

    Director:Wendey Stanzler
    Writers:Gabrielle Stanton, Harry Werksman

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  23. Grey's Anatomy Season 2 Episode 19 - What Have I Done to Deserve This?
    8.0/10(1745 votes)

    S2:E19

    Meredith and George are experiencing morning-after tension at home and at work and it has the rest of the doctors wondering what's up. Derek and Addison are experiencing their own version of morning-after tension as a result of Mark's visit to Seattle. Bailey, returning the favor that was done for her during the Code Black situation, must treat Addison for a specific feminine problem. Izzie and Alex are making headway in their relationship until Denny Duquette comes back. Soon Alex is not-so-oddly jealous of the attention Izzie is showing to Denny. Someone finds comfort in confiding in a patient who is going through an ordeal of his own. Burke deals with a patient and gets to observe the patient's unstable relationship with his fiancée.

    Director:Wendey Stanzler
    Writer:Stacy McKee

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  24. Grey's Anatomy Season 2 Episode 20 - Band-Aid Covers the Bullet Hole
    7.9/10(1687 votes)

    S2:E20

    The doctors are up to their necks in their usual levels of drama. Meredith is dealing with the backlash of sleeping with George, George and Burke are bonding in ways that bother and creep out Cristina, Cristina gets stuck on diaper duty, Bailey gets involved in a case even though she's still supposed to be on maternity leave, Addison and Derek have a talk, and Izzie is still flaking on Alex for Denny Duquette, the heart patient who didn't get a heart. In the patients-of-the-week department we've got a very pregnant woman, a hockey player who desires medically unnessasary amputation, and a woman with a fork in her neck who happens to be dying and has a struggling marriage.

    Director:Julie Anne Robinson
    Writers:Gabrielle Stanton, Harry Werksman

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  25. Grey's Anatomy Season 2 Episode 23 - Blues for Sister Someone
    7.9/10(1707 votes)

    S2:E23

    Addison's patient is a Catholic mother of seven. Addison gets in trouble after learning that the patient's husband won't use contraceptives. Derek treats a divorce attorney who asks if Derek is in need of her services. While Izzie and George are talking about their personal lives they "overhear" part of Derek's conversation with the divorce attorney who calls herself one of Seattle's best. Alex gets in trouble with Addison yet again for not being able to keep his mouth shut when other people think he should. A legendary jazz musician refuses to see medical reason. The musician is Burke's musical hero. Finn makes Meredith breakfast.

    Director:Jeff Melman
    Writers:Shonda Rhimes, Elizabeth J.B. Klaviter

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Season 2 Ratings Summary

"It's the End of the World" is the best rated episode of "Grey's Anatomy" season 2. It scored 9.4/10 based on 3740 votes. Directed by Peter Horton and written by Shonda Rhimes, it aired on 2/5/2006. This episode is rated 0.0 points higher than the second-best, "As We Know It".