After a heart-wrenching loss, Teddy struggles to cope and it triggers memories of her past. When Owen brings her home, she must face some long-standing truths. Meanwhile, Amelia tries to help the situation by encouraging Owen to accept and forgive Teddy.

Derek witnesses a horrible car accident and springs into action to save lives.

Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey's patience.

A cataclysmic event leaves the doctors shaken; Callie, on the verge of a life-changing moment, starts imagining about the hospital and her friends.

Jackson creates an uncomfortable situation when he invites new girlfriend, Vic, to what he thinks is Richard and Catherine’s anniversary celebration, only to discover the dinner was called for different reasons. Elsewhere, Levi brings Nico on a trip to visit an ailing family member.

Maggie is preoccupied with Winston while trying to treat a patient wounded in the Seattle protests. Meanwhile, Levi is tested by an emergency, and the doctors struggle to treat a patient who doesn't believe in COVID.

It’s Meredith’s last day at Grey Sloan Memorial and the doctors plan a goodbye surprise, while Nick confronts her about the future of their relationship. Elsewhere, the interns compete to scrub in on Maggie and Winston’s groundbreaking partial heart transplant procedure, and Richard asks Teddy an important question.

Simone is met with a life-changing decision upon the return of someone from her past. Blue shadows Maggie on a risky procedure, while Jo and Link tend to a pregnant woman. At the intern house, Lucas and Mika throw a party filled with surprises.

Jackson pays a visit to his father that helps set him on the right path.

Teddy makes a challenging decision. Meanwhile, Maggie and Winston aren’t on speaking terms, and Link leans on Jo for emotional support as he preps for a surgery on a well-known athlete. Simone and Lucas are surprised by an unlikely visitor.

Richard preps to present his PATH pen at the LA Surgical Innovation Conference but becomes distracted by his issues with Catherine. Maggie and Teddy run into people from their past at the same conference, while Hayes relives moments from when he met his late wife.

Grey Sloan Memorial faces new pressures as Seattle Pres is overloaded, and Grey Sloan Memorial is now on surge capacity protocol. Meanwhile, Owen and Amelia are faced with one of the most controversial surgeries of their careers.

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.

A difficult surgery brings back pivotal memories for Meredith, Richard, Owen and Stephanie, as they work together to save a life.

Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen, and Meredith gets caught between Nathan and Alex over a patient.

A wealthy inventor arrives at Grey Sloan and asks Koracick for help, while Meredith struggles to save a woman with diabetes who has been rationing her insulin. Jo and Link fight to save a young man who fell onto train tracks, and Jackson and Vic's relationship hits a snag.

The Grey Sloan doctors are stuck in the middle of a fight between a newlywed couple who are injured in a car accident and brought to the hospital for treatment. Meanwhile, Jackson’s generosity with COVID-positive patients goes a bit too far, and Hayes works to rebuild Maggie’s confidence and convince her to perform an extremely risky heart surgery.

Levi gets accepted into the vaccine trial. Meanwhile, Amelia and Owen treat a car crash patient, and Hayes and Jo are met with Luna’s legal guardian.

Meredith seeks advice from Amelia. Meanwhile, Richard is reenergized as he takes teaching to a new level at the hospital, and Winston treats a patient suffering from kidney failure.

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.

The evolution of April and Jackson’s relationship is revealed through a series of flashbacks dating back to when they first met. Simultaneously, we follow the years-long progress of one of Jackson’s patients.

As the city of Seattle revels at the Phoenix Fair celebrating the city’s rebirth post-COVID, the Grey Sloan doctors treat a patient who encounters illegal fireworks. Meanwhile, Bailey has her sights set on hiring new doctors, but she’s having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement, and Meredith has a surprising opportunity when she meets a dynamic doctor from her mother‘s past. The crossover starts on Station 19 S05E01 Phoenix from the Flame (I).

Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery. Back in Seattle, Link and Jo take their kids to a fairytale theater performance that goes wrong. Bailey and Dr. Lin attend a recruitment fair in hopes of attracting more doctors to Grey Sloan but find themselves ill-prepared.