Bailey and Ben face a huge, life-altering decision, while Meredith and several of the doctors reflect on the past.

After a heart-wrenching loss, Teddy struggles to cope and it triggers memories of her past. When Owen brings her home, she must face some long-standing truths. Meanwhile, Amelia tries to help the situation by encouraging Owen to accept and forgive Teddy.

Maggie introduces mood rooms as an alternative approach to medicine. Alex and DeLuca butt heads over an 11-year-old patient who tries to sabotage her own surgery. Jackson and Richard deal with a gender non-binary patient. Meanwhile, Teddy has a pregnancy scare that brings Owen and Koracick to odds.

Derek witnesses a horrible car accident and springs into action to save lives.

As the hospital continues to make positive changes under the new management, the doctors begin to realize that owning a hospital comes with its own set of problems and responsibilities. Meanwhile, Meredith worries about the wellbeing of her unborn baby, Callie and Arizona try to get the spark back in their relationship, and Alex gives Jo‘s new boyfriend a run for his money.

Meredith considers her loyalties, as Alex deals with the repercussions of his actions. Newlyweds Amelia and Owen host a dinner party with unlikely guests, and Jackson proposes an arrangement to help April through her recovery.

Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

A cataclysmic event leaves the doctors shaken; Callie, on the verge of a life-changing moment, starts imagining about the hospital and her friends.

Jackson creates an uncomfortable situation when he invites new girlfriend, Vic, to what he thinks is Richard and Catherine’s anniversary celebration, only to discover the dinner was called for different reasons. Elsewhere, Levi brings Nico on a trip to visit an ailing family member.

Maggie is preoccupied with Winston while trying to treat a patient wounded in the Seattle protests. Meanwhile, Levi is tested by an emergency, and the doctors struggle to treat a patient who doesn't believe in COVID.

It’s Meredith’s last day at Grey Sloan Memorial and the doctors plan a goodbye surprise, while Nick confronts her about the future of their relationship. Elsewhere, the interns compete to scrub in on Maggie and Winston’s groundbreaking partial heart transplant procedure, and Richard asks Teddy an important question.

A difficult surgery brings back pivotal memories for Meredith, Richard, Owen and Stephanie, as they work together to save a life.

Meredith is brutally attacked by a patient, and Penny is the one who discovers her. The doctors of Grey Sloan Memorial rush to stabilize Meredith and remain by her side in the harrowing aftermath.

Simone is met with a life-changing decision upon the return of someone from her past. Blue shadows Maggie on a risky procedure, while Jo and Link tend to a pregnant woman. At the intern house, Lucas and Mika throw a party filled with surprises.

Alex tries to do the right thing but still cant catch a break. Jackson and April adjust to their “new normal” with the baby. While Meredith and Nathan establish what’s going on between them, Amelia questions the state of her relationship with Owen.

Jackson pays a visit to his father that helps set him on the right path.

Teddy makes a challenging decision. Meanwhile, Maggie and Winston aren’t on speaking terms, and Link leans on Jo for emotional support as he preps for a surgery on a well-known athlete. Simone and Lucas are surprised by an unlikely visitor.

Meredith and Bailey are at odds when both of their patients need a liver transplant, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for the day, and Amelia struggles with telling Owen some important news.

Richard preps to present his PATH pen at the LA Surgical Innovation Conference but becomes distracted by his issues with Catherine. Maggie and Teddy run into people from their past at the same conference, while Hayes relives moments from when he met his late wife.

Grey Sloan Memorial faces new pressures as Seattle Pres is overloaded, and Grey Sloan Memorial is now on surge capacity protocol. Meanwhile, Owen and Amelia are faced with one of the most controversial surgeries of their careers.

The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile Meredith puts her career on the line to save a newborn in the hospital nursery, and the other interns learn that it takes more than just medical knowledge to be good at their jobs.

Meredith works on her relationship with Susan and Thatcher. Cristina has to deal with her mother and Burke's. Alex continues to tend to Jane Doe/Ava. Meredith and Derek's relationship has a problem that needs resolution quick. Addison sees her god-daughter which leads to a job offer outside of Seattle. Derek has to perform surgery. Burke has a reservation about marrying Cristina. Many new people guest star in the course of Addison's road trip to California. Addison considers moving to be closer to her old med school friends until she discovers that drama she wishes to leave behind isn't exclusive to Seattle. Her friends who she thought had it all, are divorced. A pregnant woman must discover who the father of her child is.

Jackson learns about April's pregnancy, while Alex and the team of doctors handle an hours-long triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not receiving special treatment after he and Maggie go public.

The arrival of a new consultant puts all of the doctors on edge, especially once she starts stepping on toes in the OR. Amelia and Owen bring their personal problems into the hospital, while April explores some uncharted territory.

While George is feeling a little less masculine because of the way Izzie and Meredith have been treating him (like a sister), Izzie is assigned to a patient about to loose all of his masculinity. Cristina, true to her competitive spirit, shows up early and assigns herself to an ill woman, who happens to have been Meredith's moms scrub nurse. Alex, meanwhile, is busying himself copying and pasting pictures of Izzie's racy magazine spread all over the interns' locker room. And while Meredith is trying to cope with her mother's Alzheimer's, Derek treats a patient who has managed to get nails stuck in his head.