Jordan's brother and sister return, but Dr. Cox learns that his brother-in-law Ben hasn't visited a doctor about his cancer in the two years he has been gone traveling the world.

Elliot finds herself perplexed over a simple procedure that leaves her questioning her career path. She goes to seek Dr. Kevin Casey's advice but becomes frustrated when she learns that the epiphany toilet, which the Janitor secretly installed on the roof, is getting more attention than she is. Meanwhile, Turk asks J.D. to be his best man at his wedding, which sends J.D. into sheer bliss momentarily until he hears a phone message that makes him question his friendship with Turk.

A new patient at the hospital wakes up and sees everything happening around her as a musical. Carla can't decide whether or not to return to work and Elliot must find a way to tell J.D. he can't move into her new house with her.

J.D. is planning on leaving Sacred Heart but before he goes there are a few things that he wants to do including; getting a hug from Dr. Cox, and learning the Janitor's real name. Elliot is ready for the next step in her and J.D.'s relationship and she begins moving her furniture into J.D.'s apartment.

Jordan's brother Ben is admitted at Sacred Heart for having an accident with a nail gun. J.D. learns that Ben has leukemia, but won't believe it, since there have been many mixups in the hospital lately, so he goes on a search for the real test results.

In a "Wizard of Oz" homage, J.D. is trying to go home, Turk searches for a heart donor and Carla worries, that she doesn't have the courage to become a parent. Meanwhile, Elliot doesn't believe, that she has the brains to lead a question and answer session. Also, the Janitor is painting color coded lines throughout the hospital for easier navigation.

J.D. believes he may have finally found a mentor in Dr. Kevin Casey, a surgeon with obsessive-compulsive disorder, and it turns out that Dr. Cox has always been jealous of the guy. Meanwhile, the Janitor and his new assistant help Kelso out with a garbage problem.

J.D. asks Dr. Cox out for lunch, but runs into annoying former patient Jill Tracy, who unexpectedly teaches him something about responsibility. Elliot and Carla discover that Todd has been lying about all his hospital "conquests" and suspect that he's been less than truthful about other issues. Turk warns them not to meddle in his affairs.

The three interns are each assigned patients with various illnesses. Statistically speaking, one of the three is going to die. J.D.'s patient is 86 year old Mrs. Tanner, who is in renal failure. 20 year old David Morrison is Turk's hernia patient and Elliot's patient Mrs. Guerrero only speaks Spanish and might have lupus.

J.D. and Turk make a huge sacrifice concerning a decade-long steak night tradition for a dying patient. Meanwhile, Dr. Maddox, the new Chief of Medicine, begins to show her true colors.

J.D. ditches a seemingly uninterested Kylie for Dr. Molly Clock, who just returned from Milwaukee. Carla fumes over Turk's frequent phone calls to an ex-girlfriend. The Janitor and Dr. Cox make a wager over Elliot.

J.D., Turk, Elliot and Carla are interrogated about the mysterious death of a patient. Dr. Kelso learns, that J.D. and Turk were away tracking down a patient, Elliot was traumatized over finding out that her make-out buddy was married and Carla was busy recruiting hospital personnel for a group lottery purchase.

Ben takes the news of his diagnosis pretty well - at least better than his sister Jordan and J.D. Remarkably, it is Dr. Cox who is the voice of reason and compassion, until his own fears get in the way. Meanwhile, Turk and Elliot have their own issues to deal with. Turk is upset because he wasn't chosen to assist on a difficult surgery and Elliot is criticized during rounds by Dr. Kelso for the 100th time.

Turk and Carla start to have issues when Carla tries to change everything about her new husband. Molly Clock (Heather Graham), the hospital's new psychiatrist, becomes friends with Elliot because she believes Turk, J.D. and Carla are shutting her out. Also, when Turk and J.D.'s car blows up, Carla lets him pick out the new ride only to find that instead of a car, he buys three scooters for them, further proving Carla's point that she needs to always be in control. The episode guest stars the Sugarhill Gang.

When Dan resurfaces, J.D. is shocked to learn his father has passed away. The reactions from his co-workers help J.D. a little, but the one person, Dr. Cox, who he wanted to be there for him is too busy with J.D.'s patients. Meanwhile, Dan sits drunk in the bath tub the whole day and Turk finds out he has Type II Diabetes.

When J.D. meets a former writer from his all time favorite TV show "Cheers," he begins to picture his life at the hospital as a bland, multiple camera sitcom, where everything is perfect and wraps up nicely. Back in reality, Cox is relunctant to fire an amiable cafeteria worker, while Turk and Carla struggle to keep their promise of constant romantic affection afloat.

J.D. meets the klutzy Julie, and when he becomes smitten, Elliot attempts to help out with romance advice. Meanwhile, Carla tries to find Dr. Cox's soft side, when he refuses to kiss his son. Turk and the Janitor put together an air band to win a contest, but Kelso gives them a tremendous obstacle.

Dr. Cox starts drinking after his decisions result in the death of three of his patients. The staff tries to cover for him at the hospital, while everyone tries to convince him how inspiring he is for them. Turk starts his new rotation with orthopedic surgery, but isn't so fond of his attending doctor's touchy-feely methods. Thus, J.D. and the Janitor attempt to help Turk find ways to bond with his new supervisor.

It's J.D.'s last day as an intern, and soon he will become a resident. Carla and Turk are arguing about dating other people. Elliot finally rebels against being everyone's doormat, and J.D. is just trying to stay out of people's way. Jordan has returned to get a physical and a new patient, Mr. Bober, has been admitted, because he needs his gall bladder removed. He really needs the surgery, but doesn't have the insurance to pay for it. They enlist the help of Dr. Cox, Dr. Wen and Jordan.

Jamie's (T.C.W.) husband died, and J.D. struggles with the ethical issues involved in starting a relationship with her. Dr. Cox babysits his son, whom Jordan still hasn't chosen a name for, and is disturbed that he feels nothing for the baby. Turk is haunted by erotic dreams about Elliot, which gets him into hot water with Carla.

J.D. and Turk's college buddy, Spence, drops by for a visit, and accidentally tells Dr. Cox a secret. Too much partying with successful Spence causes Turk and J.D. to show up late and drunk for work, which Dr. Kelso fully reprehends them for. Elliot's feeling low since she can't measure up to Dr. Kelso's standards, and the Janitor starts another feud – this time over paychecks – with J.D.

As J.D.'s relationship with Danni progresses, he and Dr. Cox are forced to spend more time together outside of the hospital, to Perry's great chagrin. Meanwhile, as they each deal with problems in their own relationships, Carla and Elliot work to find their own balance between their personal and professional relationships. Dr. Kelso accidentally punctures his eardrums giving the hospital staff an opportunity to tell him how they truly feel about him.

Elliot struggles to find her defining moment after Turk performs his first solo surgery. Dr. Cox deals with the reality of growing older when his back goes out. J.D. finds out that many of the hospital staff don't know the Janitor as he does.

The big day for Turk and Carla has finally arrived, but a patient holds up Turk. With Elliot still angry at him, J.D. attempts to reconcile her with Sean as a way to make everything right again in their friendship.

J.D. takes matters into his own hands, when searching for a relative for his favorite patient. Meanwhile, Elliot is fed up with coworkers not taking her serious and discovers, that she can get her way by flaunting her femininity with some help from Carla and Jordan.